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Kat6a Gene Detail
Summary
  • Symbol
    Kat6a
  • Name
    K(lysine) acetyltransferase 6A
  • Synonyms
    9930021N24Rik, MOZ, Myst3, Zfp220
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442415
    NCBI Gene: 244349
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23349551-23433275 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1270 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442415
 protein coding gene Chr8:23349458-23433275 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033460
 protein coding gene Chr8:20734961-20824396 (+)
A/J MGP_AJ_G0033440
 protein coding gene Chr8:20056629-20141493 (+)
AKR/J MGP_AKRJ_G0033365
 protein coding gene Chr8:20714947-20800050 (+)
BALB/cJ MGP_BALBcJ_G0033436
 protein coding gene Chr8:20175895-20260666 (+)
C3H/HeJ MGP_C3HHeJ_G0033150
 protein coding gene Chr8:20912847-21004362 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033952
 protein coding gene Chr8:21602192-21695130 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030904
 protein coding gene Chr8:17390415-17474524 (+)
CAST/EiJ MGP_CASTEiJ_G0032476
 protein coding gene Chr8:20328890-20419468 (+)
CBA/J MGP_CBAJ_G0033125
 protein coding gene Chr8:22460836-22563498 (+)
DBA/2J MGP_DBA2J_G0033280
 protein coding gene Chr8:20022526-20108933 (+)
FVB/NJ MGP_FVBNJ_G0033224
 protein coding gene Chr8:19822843-19904648 (+)
LP/J MGP_LPJ_G0033369
 protein coding gene Chr8:20723674-20814422 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033267
 protein coding gene Chr8:22051180-22139847 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033971
 protein coding gene Chr8:20617864-20706141 (+)
PWK/PhJ MGP_PWKPhJ_G0032188
 protein coding gene Chr8:19612216-19694612 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032021
 protein coding gene Chr8:19986573-20070342 (+)
WSB/EiJ MGP_WSBEiJ_G0032592
 protein coding gene Chr8:20819627-20909943 (+)



Homology
more
  • Human Ortholog
    KAT6A, lysine acetyltransferase 6A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KAT6A, lysine acetyltransferase 6A
  • Synonyms
    ARTHS, MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220
  • Links
    NCBI Gene ID: 7994
    neXtProt AC: NX_Q92794
    UniProt: Q92794

  • Chr Location
    8p11.21; chr8:41929479-42051994 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kat6a mouse models; 2 with human KAT6A associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 6 alleles in 10 genetic backgrounds
    12 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display perinatal lethality, cyanosis, decreased hematopoietic progenitor cell numbers, and severely impaired spleen and thymus development, but are not anemic. Heterozygotes display strain background dependent reductions in fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    48
  • cDNA Data
    128
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031540 Ensembl Gene Model | MGI Sequence Detail 83725 C57BL/6J ±  kb
    transcript ENSMUST00000238975 Ensembl | MGI Sequence Detail 9191 Not Applicable  
    polypeptide ENSMUSP00000159155 Ensembl | MGI Sequence Detail 2053 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 135
      cDNA 128
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1926208
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 13
      Phenotypes 35
    • Earliest
      J:64959 Misawa K, et al., A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3062-6
    • Latest
      J:357666 Sheridan M, et al., The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency. J Hematol Onco. 2024;17(1):91
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory