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Klf8 Gene Detail
Summary
  • Symbol
    Klf8
  • Name
    Kruppel-like transcription factor 8
  • Synonyms
    A830097P10Rik, BKLF3, ZNF74
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442430
    NCBI Gene: 245671
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:152020462-152179128 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442430
 protein coding gene ChrX:152008335-152181921 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036194
 protein coding gene ChrX:151048325-151210876 (+)
A/J MGP_AJ_G0036170
 protein coding gene ChrX:150234932-150396687 (+)
AKR/J MGP_AKRJ_G0036096
 protein coding gene ChrX:155055091-155230182 (+)
BALB/cJ MGP_BALBcJ_G0036161
 protein coding gene ChrX:148417548-148577180 (+)
C3H/HeJ MGP_C3HHeJ_G0035869
 protein coding gene ChrX:151300211-151476351 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036686
 protein coding gene ChrX:155412571-155594823 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033510
 protein coding gene ChrX:141898016-142057436 (+)
CAST/EiJ MGP_CASTEiJ_G0035160
 protein coding gene ChrX:130620971-130784295 (+)
CBA/J MGP_CBAJ_G0035846
 protein coding gene ChrX:159910253-160084355 (+)
DBA/2J MGP_DBA2J_G0036004
 protein coding gene ChrX:149280845-149456850 (+)
FVB/NJ MGP_FVBNJ_G0035938
 protein coding gene ChrX:148416436-148583373 (+)
LP/J MGP_LPJ_G0036095
 protein coding gene ChrX:152115750-152288364 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035974
 protein coding gene ChrX:168163166-168331731 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036721
 protein coding gene ChrX:150566642-150730976 (+)
PWK/PhJ MGP_PWKPhJ_G0034854
 protein coding gene ChrX:127569002-127732122 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034679
 protein coding gene ChrX:131035216-131210184 (+)
WSB/EiJ MGP_WSBEiJ_G0035295
 protein coding gene ChrX:148608242-148776162 (+)



Homology
more
  • Human Ortholog
    KLF8, KLF transcription factor 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF8, KLF transcription factor 8
  • Synonyms
    BKLF3, ZNF741
  • Links
    NCBI Gene ID: 11279
    neXtProt AC: NX_O95600
    UniProt: O95600

  • Chr Location
    Xp11.21; chrX:55908123-56291531 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    9 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A subset of male chimeras hemizygous for a gene trapped allele exhibit embryonic growth retardation. Mice heterozygous and homozygous for a gene trap allele exhibit premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    9
  • cDNA Data
    21
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041649 Ensembl Gene Model | MGI Sequence Detail 158667 C57BL/6J ±  kb
transcript ENSMUST00000039545 Ensembl | MGI Sequence Detail 4407 Not Applicable  
polypeptide ENSMUSP00000044317 Ensembl | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 21
    Primer pair 3

    Microarray probesets 1
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory