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Podxl2 Gene Detail
Summary
  • Symbol
    Podxl2
  • Name
    podocalyxin-like 2
  • Synonyms
    D130074J02Rik, Endoglycan, PODLX2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442488
    NCBI Gene: 319655
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:88819540-88852026 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    781 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442488
 protein coding gene Chr6:88819539-88852063 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031015
 protein coding gene Chr6:90256471-90288697 (-)
A/J MGP_AJ_G0030981
 protein coding gene Chr6:86787784-86821612 (-)
AKR/J MGP_AKRJ_G0030912
 protein coding gene Chr6:89265126-89297441 (-)
BALB/cJ MGP_BALBcJ_G0030994
 protein coding gene Chr6:86775362-86808413 (-)
C3H/HeJ MGP_C3HHeJ_G0030716
 protein coding gene Chr6:95142928-95176819 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031451
 protein coding gene Chr6:92673373-92707316 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028633
 protein coding gene Chr6:84939409-84972043 (-)
CAST/EiJ MGP_CASTEiJ_G0030103
 protein coding gene Chr6:89383322-89417087 (-)
CBA/J MGP_CBAJ_G0030678
 protein coding gene Chr6:96216205-96248467 (-)
DBA/2J MGP_DBA2J_G0030834
 protein coding gene Chr6:86067223-86099747 (-)
FVB/NJ MGP_FVBNJ_G0030787
 protein coding gene Chr6:85260967-85297815 (-)
LP/J MGP_LPJ_G0030911
 protein coding gene Chr6:90282613-90323108 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030820
 protein coding gene Chr6:100322870-100357214 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031478
 protein coding gene Chr6:89129835-89162498 (-)
PWK/PhJ MGP_PWKPhJ_G0029818
 protein coding gene Chr6:85048927-85081984 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029646
 protein coding gene Chr6:87936499-87973959 (-)
WSB/EiJ MGP_WSBEiJ_G0030184
 protein coding gene Chr6:89583566-89617331 (-)



Homology
more
  • Human Ortholog
    PODXL2, podocalyxin like 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PODXL2, podocalyxin like 2
  • Synonyms
    EG, PODLX2
  • Links
    NCBI Gene ID: 50512
    neXtProt AC: NX_Q9NZ53
    UniProt: Q9NZ53

  • Chr Location
    chr3:127629185-127672802 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are healthy and exhibit normal kidney morphology and normal nephron lumen and pancreatic lumen formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    60
  • cDNA Data
    8
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033152 Ensembl Gene Model | MGI Sequence Detail 32487 C57BL/6J ±  kb
    transcript ENSMUST00000145944 Ensembl | MGI Sequence Detail 2065 Not Applicable  
    polypeptide ENSMUSP00000117954 Ensembl | MGI Sequence Detail 603 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory