Agmo MGI Mouse Gene Detail - MGI:2442495 - alkylglycerol monooxygenase

Symbol

Agmo
Name

alkylglycerol monooxygenase
Synonyms

A530016O06Rik, Tmem195

Feature Type

protein coding gene
IDs

MGI:2442495
NCBI Gene: 319660
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr12:37291640-37632201 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 16.84 cM
Mapping Data

2 experiments

SNPs within 2kb

10132 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442495	protein coding gene	Chr12:37291638-37632201 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019696	protein coding gene	Chr12:35505198-35859581 (+)
A/J	MGP_AJ_G0019662	protein coding gene	Chr12:34377113-34714453 (+)
AKR/J	MGP_AKRJ_G0019633	protein coding gene	Chr12:35430323-35771135 (+)
BALB/cJ	MGP_BALBcJ_G0019640	protein coding gene	Chr12:34587845-34938840 (+)
C3H/HeJ	MGP_C3HHeJ_G0019444	protein coding gene	Chr12:35372847-35714464 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020087	protein coding gene	Chr12:36513565-36903644 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017711	protein coding gene	Chr12:33462396-33819010 (+)
CAST/EiJ	MGP_CASTEiJ_G0018997	protein coding gene	Chr12:30444742-30813483 (+)
CBA/J	MGP_CBAJ_G0019416	protein coding gene	Chr12:37708033-38109343 (+)
DBA/2J	MGP_DBA2J_G0019529	protein coding gene	Chr12:34219536-34568092 (+)
FVB/NJ	MGP_FVBNJ_G0019518	protein coding gene	Chr12:33929984-34275063 (+)
LP/J	MGP_LPJ_G0019599	protein coding gene	Chr12:35606137-35978818 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019554	protein coding gene	Chr12:37531148-37993598 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020127	protein coding gene	Chr12:34965238-35323387 (+)
PWK/PhJ	MGP_PWKPhJ_G0018764	protein coding gene	Chr12:28908803-29248139 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018554	protein coding gene	Chr12:29618228-29958234 (+)
WSB/EiJ	MGP_WSBEiJ_G0019047	protein coding gene	Chr12:35237867-35612291 (+)

Human Ortholog

AGMO, alkylglycerol monooxygenase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGMO, alkylglycerol monooxygenase
Synonyms

TMEM195
Links

HGNC:33784

NCBI Gene ID: 392636

neXtProt AC: NX_Q6ZNB7

UniProt: Q6ZNB7
Chr Location

7p21.2; chr7:15117223-15562015 (-) GRCh38

MGI Vertebrate Homology

Agmo stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGMO
Gene Tree

Agmo

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Phenotype Summary

7 phenotypes from 3 alleles in 4 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele lack alkylglycerol monooxygenase activity but exhibit no overt phenotype under standard housing conditions. Male mice show reduced circulating cholesterol levels and modest increases only in plasmanyl and plasmenyl ether lipids.

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase agmo

ZFIN agmo

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All Sequences

43
RefSeq

5
UniProt

2
CCDS

CCDS49052.1

Ensembl

ENSMUSG00000050103 (Evidence)
NCBI Gene

319660

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050103	Ensembl Gene Model \| MGI Sequence Detail	340562	C57BL/6J	± kb
transcript	ENSMUST00000049874	Ensembl \| MGI Sequence Detail	2423	Not Applicable
polypeptide	ENSMUSP00000051441	Ensembl \| MGI Sequence Detail	447	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029266 alkylglycerol monooxygenase

(term hierarchy)
EC

1.14.16.5
InterPro Domains

IPR006694 Fatty acid hydroxylase

IPR051689 Sterol Desaturase/TMEM195-like
GlyGen

Q8BS35 1 site, 3 N-linked glycans (1 site)

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All nucleic 8

cDNA 8

Microarray probesets 3

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MGI:2144885

Summaries

All 33

Gene Ontology 7

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Agmo:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113252	Chr12:37291619-37291630 (+)	-15 bp
Tssr113253	Chr12:37291632-37291653 (+)	3 bp
Tssr113254	Chr12:37291667-37291682 (+)	35 bp
Tssr113255	Chr12:37291728-37291757 (+)	103 bp
Tssr113256	Chr12:37291765-37291783 (+)	134 bp
Tssr113257	Chr12:37291803-37291896 (+)	210 bp
Tssr113258	Chr12:37291898-37291903 (+)	261 bp
Tssr113259	Chr12:37291904-37291920 (+)	272 bp
Tssr113260	Chr12:37291924-37291938 (+)	291 bp
Tssr113261	Chr12:37292000-37292007 (+)	364 bp
Tssr113262	Chr12:37292029-37292038 (+)	394 bp
Tssr113263	Chr12:37292064-37292097 (+)	441 bp
Tssr113264	Chr12:37466686-37466689 (+)	175,048 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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