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Lactb2 Gene Detail
Summary
  • Symbol
    Lactb2
  • Name
    lactamase, beta 2
  • Synonyms
    Cgi-83, E430032H21Rik, MGC:7674
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442551
    NCBI Gene: 212442
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:13695069-13730749 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 4.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1380 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442551
 protein coding gene Chr1:13693554-13730770 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015843
 protein coding gene Chr1:10998557-11036464 (-)
A/J MGP_AJ_G0015825
 protein coding gene Chr1:10950168-10988042 (-)
AKR/J MGP_AKRJ_G0015784
 protein coding gene Chr1:10886469-10925469 (-)
BALB/cJ MGP_BALBcJ_G0015781
 protein coding gene Chr1:10649999-10688678 (-)
C3H/HeJ MGP_C3HHeJ_G0015615
 protein coding gene Chr1:10851754-10898072 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016235
 protein coding gene Chr1:11523288-11561766 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013956
 protein coding gene Chr1:9565162-9602897 (-)
CAST/EiJ MGP_CASTEiJ_G0015195
 protein coding gene Chr1:11052465-11089014 (-)
CBA/J MGP_CBAJ_G0015588
 protein coding gene Chr1:11764560-11809111 (-)
DBA/2J MGP_DBA2J_G0015687
 protein coding gene Chr1:10560444-10598069 (-)
FVB/NJ MGP_FVBNJ_G0015692
 protein coding gene Chr1:10374059-10410631 (-)
LP/J MGP_LPJ_G0015759
 protein coding gene Chr1:11187582-11224698 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015711
 protein coding gene Chr1:12485133-12522437 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016282
 protein coding gene Chr1:10793248-10830985 (-)
PWK/PhJ MGP_PWKPhJ_G0014979
 protein coding gene Chr1:10371718-10411836 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014760
 protein coding gene Chr1:11017214-11054461 (-)
WSB/EiJ MGP_WSBEiJ_G0015259
 protein coding gene Chr1:10808172-10846240 (-)



Homology
more
  • Human Ortholog
    LACTB2, lactamase beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LACTB2, lactamase beta 2
  • Synonyms
    CGI-83
  • Links
    NCBI Gene ID: 51110
    neXtProt AC: NX_Q53H82
    UniProt: Q53H82

  • Chr Location
    8q13.3; chr8:70635318-70669185 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from multigenic genotypes
    5 phenotype references
Male mice homozygous for a null allele exhibit at 40 days of age preceeded by decreased body size, lethargy, enlarged and pale liver and hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    22
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 212442 NCBI Gene Model | MGI Sequence Detail 35681 C57BL/6J ±  kb
transcript NR_184544 RefSeq | MGI Sequence Detail 3111 C57BL/6  
polypeptide Q99KR3 UniProt | EBI | MGI Sequence Detail 288 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 6
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:79618 Sollars VE, et al., A novel transgenic line of mice exhibiting autosomal recessive male-specific lethality and non-alcoholic fatty liver disease. Hum Mol Genet. 2002 Nov 1;11(22):2777-86
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory