Cers6 Gene Detail

Summary

• Symbol
  Cers6
• Name
  ceramide synthase 6
• Synonyms
  4732462C07Rik, CerS6, Lass6, similar to TRH1, T1L

• Feature Type
  protein coding gene
• IDs
  MGI:2442564
  NCBI Gene: 241447
• Alliance
  gene page
• Transcription Start Sites
  62 TSS

Location &
Maps

• Sequence Map
  Chr2:68691785-68944626 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 39.53 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  7035 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442564	protein coding gene	Chr2:68691489-68944628 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025793	protein coding gene	Chr2:68780279-69038614 (+)
A/J	MGP_AJ_G0025770	protein coding gene	Chr2:66133837-66384945 (+)
AKR/J	MGP_AKRJ_G0025739	protein coding gene	Chr2:67912842-68172543 (+)
BALB/cJ	MGP_BALBcJ_G0025765	protein coding gene	Chr2:66305873-66563382 (+)
C3H/HeJ	MGP_C3HHeJ_G0025525	protein coding gene	Chr2:68140773-68400190 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026212	protein coding gene	Chr2:70865831-71127806 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023615	protein coding gene	Chr2:63377269-63626424 (+)
CAST/EiJ	MGP_CASTEiJ_G0024989	protein coding gene	Chr2:68237734-68496259 (+)
CBA/J	MGP_CBAJ_G0025505	protein coding gene	Chr2:73455577-73724483 (+)
DBA/2J	MGP_DBA2J_G0025636	protein coding gene	Chr2:65776886-66026556 (+)
FVB/NJ	MGP_FVBNJ_G0025599	protein coding gene	Chr2:65155384-65401667 (+)
LP/J	MGP_LPJ_G0025725	protein coding gene	Chr2:68644155-68906341 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025628	protein coding gene	Chr2:75534948-75794105 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026269	protein coding gene	Chr2:68003639-68264051 (+)
PWK/PhJ	MGP_PWKPhJ_G0024730	protein coding gene	Chr2:65609127-65860373 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024537	protein coding gene	Chr2:68219844-68488644 (+)
WSB/EiJ	MGP_WSBEiJ_G0025057	protein coding gene	Chr2:68423183-68680168 (+)

Homology

• Human Ortholog
  CERS6, ceramide synthase 6

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CERS6, ceramide synthase 6
  
• Synonyms
  CERS5, LASS6
• Links
  HGNC:23826

  NCBI Gene ID: 253782

  neXtProt AC: NX_Q6ZMG9

  UniProt: Q6ZMG9

  
  
• Chr Location
  2q24.3; chr2:168456249-168775134 (+)  GRCh38

---

• MGI Vertebrate Homology
  Cers6 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CERS6
• Protein SuperFamily
  LAG1_LAC1
• Gene Tree
  Cers6
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  24 phenotypes from 3 alleles in 4 genetic backgrounds
  1 images
  20 phenotype references
  

• All Mutations and Alleles
  30
• Chemically induced (other)
  1
• Endonuclease-mediated
  5
• Gene trapped
  19
• Targeted
  5
• Genomic Mutations
  1 involving Cers6
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  42 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knockout allele exhibit hind limb clasping, habituation deficit and altered lipid homeostasis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  15
• GO References
  9

Expression

• Assay Results
  750
• Tissues
  27
• cDNA Data
  12
• Literature Summary
  8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA CERS6
  ZFIN cers6

Sequences &
Gene Models

• All Sequences
  50
• RefSeq
  7
• UniProt
  2
• CCDS
  CCDS16086.1, CCDS84532.1

• Ensembl
  ENSMUSG00000027035 (Evidence)
• NCBI Gene
  241447

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000027035	Ensembl Gene Model | MGI Sequence Detail	252842	C57BL/6J
transcript	ENSMUST00000176018	Ensembl | MGI Sequence Detail	1279	Not Applicable
polypeptide	ENSMUSP00000135604	Ensembl | MGI Sequence Detail	392	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000009682 ceramide synthase 6
  (term hierarchy)
• PDB
  1X2M
• EC
  2.3.1.-, 2.3.1.291
• InterPro Domains
  IPR001356 Homeobox domain
  IPR009057 Homeobox-like domain superfamily
  IPR016439 Sphingosine N-acyltransferase Lag1/Lac1-like
  IPR006634 TRAM/LAG1/CLN8 homology domain
• GlyGen
  Q8C172 2 sites, 5 N-linked glycans (1 site), 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 13

  cDNA 12

  Primer pair 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2139372

References

• Summaries
  All 60

  Developmental Gene Expression 8

  Gene Ontology 9

  Phenotypes 20
• Earliest
  J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
• Latest
  J:346053 Zhang J, et al., Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat Commun. 2024 Mar 14;15(1):2315

TSS for Cers6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18033	Chr2:68691422-68691433 (+)	-357 bp
Tssr18034	Chr2:68691454-68691498 (+)	-309 bp
Tssr18035	Chr2:68691777-68691854 (+)	31 bp
Tssr18036	Chr2:68691908-68691919 (+)	129 bp
Tssr18038	Chr2:68699265-68699295 (+)	7,495 bp
Tssr18039	Chr2:68700720-68700744 (+)	8,947 bp
Tssr18040	Chr2:68705411-68705414 (+)	13,628 bp
Tssr18041	Chr2:68708296-68708311 (+)	16,519 bp
Tssr18042	Chr2:68713894-68713914 (+)	22,119 bp
Tssr18044	Chr2:68729219-68729237 (+)	37,443 bp
Tssr18048	Chr2:68741957-68741973 (+)	50,180 bp
Tssr18049	Chr2:68743909-68743921 (+)	52,130 bp
Tssr18050	Chr2:68744013-68744021 (+)	52,232 bp
Tssr18051	Chr2:68756435-68756440 (+)	64,653 bp
Tssr18052	Chr2:68766603-68766612 (+)	74,823 bp
Tssr18053	Chr2:68769872-68769884 (+)	78,093 bp
Tssr18054	Chr2:68770968-68770988 (+)	79,193 bp
Tssr18055	Chr2:68772173-68772184 (+)	80,394 bp
Tssr18056	Chr2:68790162-68790178 (+)	98,385 bp
Tssr18057	Chr2:68790183-68790194 (+)	98,404 bp
Tssr18061	Chr2:68799181-68799186 (+)	107,399 bp
Tssr18062	Chr2:68801189-68801197 (+)	109,408 bp
Tssr18063	Chr2:68809533-68809553 (+)	117,758 bp
Tssr18064	Chr2:68809794-68809817 (+)	118,021 bp
Tssr18065	Chr2:68809847-68809850 (+)	118,064 bp
Tssr18066	Chr2:68809993-68810012 (+)	118,218 bp
Tssr18068	Chr2:68830218-68830230 (+)	138,439 bp
Tssr18069	Chr2:68830291-68830305 (+)	138,513 bp
Tssr18070	Chr2:68830308-68830319 (+)	138,529 bp
Tssr18071	Chr2:68830323-68830335 (+)	138,544 bp
Tssr18072	Chr2:68830708-68830715 (+)	138,927 bp
Tssr18073	Chr2:68835182-68835193 (+)	143,403 bp
Tssr18074	Chr2:68835653-68835663 (+)	143,873 bp
Tssr18075	Chr2:68838742-68838762 (+)	146,967 bp
Tssr18076	Chr2:68838764-68838779 (+)	146,987 bp
Tssr18077	Chr2:68838786-68838799 (+)	147,008 bp
Tssr18078	Chr2:68838878-68838891 (+)	147,100 bp
Tssr18079	Chr2:68838924-68838939 (+)	147,147 bp
Tssr18080	Chr2:68838949-68838959 (+)	147,169 bp
Tssr18081	Chr2:68853266-68853277 (+)	161,487 bp
Tssr18082	Chr2:68853305-68853323 (+)	161,529 bp
Tssr18083	Chr2:68853326-68853362 (+)	161,559 bp
Tssr18084	Chr2:68861778-68861797 (+)	170,003 bp
Tssr18085	Chr2:68866232-68866251 (+)	174,457 bp
Tssr18086	Chr2:68866371-68866378 (+)	174,590 bp
Tssr18087	Chr2:68866412-68866433 (+)	174,638 bp
Tssr18088	Chr2:68888118-68888134 (+)	196,341 bp
Tssr18089	Chr2:68901737-68901754 (+)	209,961 bp
Tssr18090	Chr2:68905866-68905880 (+)	214,088 bp
Tssr18091	Chr2:68922211-68922215 (+)	230,428 bp
Tssr18092	Chr2:68922984-68923003 (+)	231,209 bp
Tssr18093	Chr2:68923417-68923437 (+)	231,642 bp
Tssr18094	Chr2:68924156-68924164 (+)	232,375 bp
Tssr18095	Chr2:68935401-68935420 (+)	243,626 bp
Tssr18096	Chr2:68939866-68939883 (+)	248,090 bp
Tssr18097	Chr2:68940213-68940236 (+)	248,440 bp
Tssr18098	Chr2:68940282-68940299 (+)	248,506 bp
Tssr18099	Chr2:68941510-68941522 (+)	249,731 bp
Tssr18100	Chr2:68942882-68942927 (+)	251,120 bp
Tssr18101	Chr2:68943904-68943915 (+)	252,125 bp
Tssr18102	Chr2:68943926-68943947 (+)	252,152 bp
Tssr18103	Chr2:68944148-68944154 (+)	252,366 bp