Frmd6 MGI Mouse Gene Detail - MGI:2442579

Symbol

Frmd6
Name

FERM domain containing 6
Synonyms

2610019M19Rik, 4930488L10Rik

Feature Type

protein coding gene
IDs

MGI:2442579
NCBI Gene: 319710
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:70872288-70949008 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 29.37 cM
Mapping Data

2 experiments

SNPs within 2kb

2442 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442579	protein coding gene	Chr12:70872235-70949009 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019811	protein coding gene	Chr12:70594925-70673862 (+)
A/J	MGP_AJ_G0019769	protein coding gene	Chr12:67959438-68036506 (+)
AKR/J	MGP_AKRJ_G0019745	protein coding gene	Chr12:69989726-70070610 (+)
BALB/cJ	MGP_BALBcJ_G0019749	protein coding gene	Chr12:68416413-68493515 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0020201	protein coding gene	Chr12:72851324-72932906 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017821	protein coding gene	Chr12:65475167-65549628 (+)
CAST/EiJ	MGP_CASTEiJ_G0019106	protein coding gene	Chr12:65221496-65299915 (+)
CBA/J	MGP_CBAJ_G0019524	protein coding gene	Chr12:75540889-75623665 (+)
DBA/2J	MGP_DBA2J_G0019640	protein coding gene	Chr12:67864938-67942159 (+)
FVB/NJ	MGP_FVBNJ_G0019627	protein coding gene	Chr12:66763708-66842618 (+)
LP/J	MGP_LPJ_G0019712	protein coding gene	Chr12:70585638-70663583 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0020236	protein coding gene	Chr12:69488825-69567831 (+)
PWK/PhJ	MGP_PWKPhJ_G0018871	protein coding gene	Chr12:62148036-62226922 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018666	protein coding gene	Chr12:63861854-63938551 (+)
WSB/EiJ	MGP_WSBEiJ_G0019157	protein coding gene	Chr12:70097424-70176316 (+)

Human Ortholog

FRMD6, FERM domain containing 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FRMD6, FERM domain containing 6
Synonyms

c14_5320, C14orf31, EX1, Willin
Links

HGNC:19839

NCBI Gene ID: 122786

neXtProt AC: NX_Q96NE9

UniProt: Q96NE9
Chr Location

14q22.1; chr14:51396431-51730727 (+) GRCh38

MGI Vertebrate Homology

Frmd6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FRMD6
Gene Tree

Frmd6

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

5
Genomic Mutations

1 involving Frmd6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

6
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase frmd6

ZFIN frmd6

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All Sequences

50
RefSeq

12
UniProt

2
CCDS

CCDS25959.1

Ensembl

ENSMUSG00000048285 (Evidence)
NCBI Gene

319710

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048285	Ensembl Gene Model \| MGI Sequence Detail	76721	C57BL/6J	± kb
transcript	ENSMUST00000057859	Ensembl \| MGI Sequence Detail	4662	Not Applicable
polypeptide	ENSMUSP00000052202	Ensembl \| MGI Sequence Detail	622	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031409 FERM domain-containing protein 6

(term hierarchy)
InterPro Domains

IPR019749 Band 4.1 domain

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR019748 FERM central domain

IPR018980 FERM, C-terminal PH-like domain

IPR000299 FERM domain

IPR041781 FERM domain-containing protein 6, FERM domain C-lobe

IPR047145 FERM domain-containing protein 6-like

IPR018979 FERM, N-terminal

IPR035963 FERM superfamily, second domain

IPR011993 PH-like domain superfamily

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 5

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MGI:1919400, MGI:2145018

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Frmd6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113692	Chr12:70872224-70872253 (+)	-49 bp
Tssr113693	Chr12:70872266-70872288 (+)	-11 bp
Tssr113694	Chr12:70889495-70889499 (+)	17,209 bp
Tssr113695	Chr12:70899707-70899711 (+)	27,421 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24