Simc1 MGI Mouse Gene Detail - MGI:2442599 - SUMO-interacting motifs containing 1

Symbol

Simc1
Name

SUMO-interacting motifs containing 1
Synonyms

4732471D19Rik

Feature Type

protein coding gene
IDs

MGI:2442599
NCBI Gene: 319719
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:54651592-54699103 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 28.74 cM
Mapping Data

2 experiments

SNPs within 2kb

862 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442599	protein coding gene	Chr13:54651539-54699103 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020569	protein coding gene	Chr13:53905329-53952567 (+)
A/J	MGP_AJ_G0020523	protein coding gene	Chr13:51930789-51976543 (+)
AKR/J	MGP_AKRJ_G0020501	protein coding gene	Chr13:53457633-53503918 (+)
BALB/cJ	MGP_BALBcJ_G0020519	protein coding gene	Chr13:52159156-52204903 (+)
C3H/HeJ	MGP_C3HHeJ_G0020318	protein coding gene	Chr13:53278844-53327575 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020953	protein coding gene	Chr13:55556989-55608783 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018535	protein coding gene	Chr13:49926411-49970522 (+)
CAST/EiJ	MGP_CASTEiJ_G0019832	protein coding gene	Chr13:53352171-53406076 (+)
CBA/J	MGP_CBAJ_G0020278	protein coding gene	Chr13:57662243-57717951 (+)
DBA/2J	MGP_DBA2J_G0020401	protein coding gene	Chr13:51497127-51544659 (+)
FVB/NJ	MGP_FVBNJ_G0020380	protein coding gene	Chr13:50945750-50991648 (+)
LP/J	MGP_LPJ_G0020477	protein coding gene	Chr13:54179297-54228114 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020409	protein coding gene	Chr13:57162284-57218483 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020996	protein coding gene	Chr13:53048560-53096535 (+)
PWK/PhJ	MGP_PWKPhJ_G0019588	protein coding gene	Chr13:51475574-51528689 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019415	protein coding gene	Chr13:51956672-52008269 (+)
WSB/EiJ	MGP_WSBEiJ_G0019894	protein coding gene	Chr13:53380710-53429870 (+)

Human Ortholog

SIMC1, SUMO interacting motifs containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SIMC1, SUMO interacting motifs containing 1
Synonyms

C5orf25, OOMA1, PLEIAD
Links

HGNC:24779

NCBI Gene ID: 375484

neXtProt AC: NX_Q8NDZ2

UniProt: Q8NDZ2
Chr Location

5q35.2; chr5:176238367-176345991 (+) GRCh38

MGI Vertebrate Homology

Simc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SIMC1
Gene Tree

Simc1

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References

1 with disease annotations

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Genomic Mutations

2 involving Simc1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

58 strains or lines available

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

69

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

70
RefSeq

16
UniProt

7
CCDS

CCDS26528.2

Ensembl

ENSMUSG00000043183 (Evidence)
NCBI Gene

319719

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043183	Ensembl Gene Model \| MGI Sequence Detail	47512	C57BL/6J	± kb
transcript	ENSMUST00000121401	Ensembl \| MGI Sequence Detail	4819	Not Applicable
polypeptide	ENSMUSP00000113676	Ensembl \| MGI Sequence Detail	1354	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000059961 SUMO-interacting motif-containing protein 1

(term hierarchy)
InterPro Domains

IPR052119 Elongin BC-PRC2 Interaction & Viral Restriction

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All nucleic 69

cDNA 69

Microarray probesets 5

Summaries

All 33

Diseases 1

Gene Ontology 4

Phenotypes 9
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:190741 Migdalska AM, et al., Generation of the Sotos syndrome deletion in mice. Mamm Genome. 2012 Dec;23(11-12):749-57

TSS for Simc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119870	Chr13:54651575-54651582 (+)	-13 bp
Tssr119871	Chr13:54651599-54651613 (+)	14 bp
Tssr119872	Chr13:54665317-54665321 (+)	13,727 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24