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Plcxd3 Gene Detail
Summary
  • Symbol
    Plcxd3
  • Name
    phosphatidylinositol-specific phospholipase C, X domain containing 3
  • Synonyms
    B130016O10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442605
    NCBI Gene: 239318
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:4404973-4605035 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 1.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4915 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442605
 protein coding gene Chr15:4404973-4605067 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021686
 protein coding gene Chr15:1252952-1460326 (+)
A/J MGP_AJ_G0021646
 protein coding gene Chr15:1268002-1469743 (+)
AKR/J MGP_AKRJ_G0021624
 protein coding gene Chr15:1259390-1468471 (+)
BALB/cJ MGP_BALBcJ_G0021653
 protein coding gene Chr15:1226114-1426332 (+)
C3H/HeJ MGP_C3HHeJ_G0021429
 protein coding gene Chr15:1271607-1487634 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022092
 protein coding gene Chr15:1346268-1558358 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019630
 protein coding gene Chr15:1093423-1277701 (+)
CAST/EiJ MGP_CASTEiJ_G0020946
 protein coding gene Chr15:1293023-1499817 (+)
CBA/J MGP_CBAJ_G0021398
 protein coding gene Chr15:1356638-1584004 (+)
DBA/2J MGP_DBA2J_G0021522
 protein coding gene Chr15:1245134-1434604 (+)
FVB/NJ MGP_FVBNJ_G0021500
 protein coding gene Chr15:1184657-1377832 (+)
LP/J MGP_LPJ_G0021589
 protein coding gene Chr15:1223236-1405776 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021526
 protein coding gene Chr15:1425592-1665693 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022115
 protein coding gene Chr15:1258096-1472345 (+)
PWK/PhJ MGP_PWKPhJ_G0020689
 protein coding gene Chr15:1254953-1449370 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020527
 protein coding gene Chr15:1305974-1492232 (+)
WSB/EiJ MGP_WSBEiJ_G0021001
 protein coding gene Chr15:1236204-1437183 (+)



Homology
more
  • Human Ortholog
    PLCXD3, phosphatidylinositol specific phospholipase C X domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCXD3, phosphatidylinositol specific phospholipase C X domain containing 3
  • Links
    NCBI Gene ID: 345557
    neXtProt AC: NX_Q63HM9
    UniProt: Q63HM9

  • Chr Location
    5p13.1; chr5:41306952-41510601 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049148 Ensembl Gene Model | MGI Sequence Detail 200063 C57BL/6J ±  kb
transcript ENSMUST00000061925 Ensembl | MGI Sequence Detail 1851 Not Applicable  
polypeptide ENSMUSP00000053553 Ensembl | MGI Sequence Detail 321 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030244 PI-PLC X domain-containing protein 3
    (term hierarchy)
  • InterPro Domains
    IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
    IPR051057 Phosphoinositide phospholipase C domain-containing protein
    IPR042158 PI-PLC X domain-containing protein 1/2/3
    IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:341393 Cheffer A, et al., DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. Cereb Cortex. 2023 Sep 26;33(19):10272-10285
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory