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Nup133 Gene Detail
Summary
  • Symbol
    Nup133
  • Name
    nucleoporin 133
  • Synonyms
    4832420O05Rik, mermaid
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442620
    NCBI Gene: 234865
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124623862-124676004 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.27 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442620
 protein coding gene Chr8:124623862-124676019 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034265
 protein coding gene Chr8:127538184-127590496 (-)
A/J MGP_AJ_G0034245
 protein coding gene Chr8:122280954-122333352 (-)
AKR/J MGP_AKRJ_G0034172
 protein coding gene Chr8:125795536-125849568 (-)
BALB/cJ MGP_BALBcJ_G0034238
 protein coding gene Chr8:122464919-122518431 (-)
C3H/HeJ MGP_C3HHeJ_G0033949
 protein coding gene Chr8:126430444-126483603 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034758
 protein coding gene Chr8:131823806-131875922 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031699
 protein coding gene Chr8:115057459-115109257 (-)
CAST/EiJ MGP_CASTEiJ_G0033276
 protein coding gene Chr8:126542124-126595302 (-)
CBA/J MGP_CBAJ_G0033922
 protein coding gene Chr8:136635785-136696478 (-)
DBA/2J MGP_DBA2J_G0034078
 protein coding gene Chr8:121433320-121485843 (-)
FVB/NJ MGP_FVBNJ_G0034022
 protein coding gene Chr8:120596140-120648865 (-)
LP/J MGP_LPJ_G0034167
 protein coding gene Chr8:127702243-127756147 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034069
 protein coding gene Chr8:138770163-138823116 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034777
 protein coding gene Chr8:126025033-126081368 (-)
PWK/PhJ MGP_PWKPhJ_G0032978
 protein coding gene Chr8:121189550-121242614 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032817
 protein coding gene Chr8:124667444-124723450 (-)
WSB/EiJ MGP_WSBEiJ_G0033393
 protein coding gene Chr8:126753839-126806424 (-)



Homology
more
  • Human Ortholog
    NUP133, nucleoporin 133
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUP133, nucleoporin 133
  • Synonyms
    GAMOS8, hNUP133, NPHS18
  • Links
    NCBI Gene ID: 55746
    neXtProt AC: NX_Q8WUM0
    UniProt: Q8WUM0

  • Chr Location
    1q42.13; chr1:229440259-229508341 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NUP133 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality prior to E10.5, abnormal somitogenesis, pericardial edema, growth retardation, and abnormal neural development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    27
  • cDNA Data
    124
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039509 Ensembl Gene Model | MGI Sequence Detail 52143 C57BL/6J ±  kb
    transcript ENSMUST00000044795 Ensembl | MGI Sequence Detail 5808 Not Applicable  
    polypeptide ENSMUSP00000048084 Ensembl | MGI Sequence Detail 1155 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011507 nuclear pore complex protein Nup133
      (term hierarchy)
    • InterPro Domains
      IPR037624 Nuclear pore complex protein Nup133-like
      IPR007187 Nucleoporin, Nup133/Nup155-like, C-terminal
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q8R0G9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 124
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:3578197
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:114003 Belgareh N, et al., An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J Cell Biol. 2001 Sep 17;154(6):1147-60
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory