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Ints15 Gene Detail
Summary
  • Symbol
    Ints15
  • Name
    integrator complex subunit 15
  • Synonyms
    E130309D02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442621
    NCBI Gene: 231868
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143286950-143301115 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 82.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    457 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442621
 protein coding gene Chr5:143286827-143301147 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030328
 protein coding gene Chr5:148622653-148636802 (-)
A/J MGP_AJ_G0030297
 protein coding gene Chr5:142246517-142260778 (-)
AKR/J MGP_AKRJ_G0030229
 protein coding gene Chr5:146705796-146719952 (-)
BALB/cJ MGP_BALBcJ_G0030314
 protein coding gene Chr5:143497809-143511968 (-)
C3H/HeJ MGP_C3HHeJ_G0030025
 protein coding gene Chr5:147516969-147531116 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030759
 protein coding gene Chr5:154054397-154068544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027977
 protein coding gene Chr5:136025764-136040026 (-)
CAST/EiJ MGP_CASTEiJ_G0029430
 protein coding gene Chr5:147008476-147027691 (-)
CBA/J MGP_CBAJ_G0029995
 protein coding gene Chr5:160405165-160419379 (-)
DBA/2J MGP_DBA2J_G0030145
 protein coding gene Chr5:142013222-142027376 (-)
FVB/NJ MGP_FVBNJ_G0030100
 protein coding gene Chr5:141223505-141238107 (-)
LP/J MGP_LPJ_G0030231
 protein coding gene Chr5:149228800-149242948 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030131
 protein coding gene Chr5:162804794-162818960 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030799
 protein coding gene Chr5:146551127-146565340 (-)
PWK/PhJ MGP_PWKPhJ_G0029145
 protein coding gene Chr5:141099241-141113592 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028981
 protein coding gene Chr5:144288751-144304113 (-)
WSB/EiJ MGP_WSBEiJ_G0029503
 protein coding gene Chr5:147341227-147355436 (-)



Homology
more
  • Human Ortholog
    INTS15, integrator complex subunit 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTS15, integrator complex subunit 15
  • Synonyms
    C7orf26
  • Links
    NCBI Gene ID: 79034
    neXtProt AC: NX_Q96N11
    UniProt: Q96N11

  • Chr Location
    7p22.1; chr7:6590021-6608726 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion in exon 2 are embryonic lethal while heterozygotes show severe ocular malformations, including persistence of fetal vasculature, chorioretinal atrophy, corneal opacity, cataract and optic nerve anomaly. Mice with a heterozygous or homozygous deletion in exon 6 exhibit milder eye phenotypes at a lower incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    24
  • cDNA Data
    52
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039244 Ensembl Gene Model | MGI Sequence Detail 14166 C57BL/6J ±  kb
    transcript ENSMUST00000046418 Ensembl | MGI Sequence Detail 2208 Not Applicable  
    polypeptide ENSMUSP00000041800 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:6885575, MGI:7276233
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 4
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:337973 Azuma N, et al., Integrator complex subunit 15 controls mRNA splicing and is critical for eye development. Hum Mol Genet. 2023 Jun 5;32(12):2032-2045
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory