Hectd2 MGI Mouse Gene Detail - MGI:2442663 - HECT domain E3 ubiquitin protein ligase 2

Symbol

Hectd2
Name

HECT domain E3 ubiquitin protein ligase 2
Synonyms

A630025O09Rik

Feature Type

protein coding gene
IDs

MGI:2442663
NCBI Gene: 226098
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:36532039-36598535 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 31.77 cM
Mapping Data

2 experiments

SNPs within 2kb

2061 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442663	protein coding gene	Chr19:36531420-36598535 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025072	protein coding gene	Chr19:35440972-35511550 (+)
A/J	MGP_AJ_G0025048	protein coding gene	Chr19:33748581-33816242 (+)
AKR/J	MGP_AKRJ_G0025016	protein coding gene	Chr19:34872627-34940365 (+)
BALB/cJ	MGP_BALBcJ_G0025046	protein coding gene	Chr19:33832079-33899585 (+)
C3H/HeJ	MGP_C3HHeJ_G0024805	protein coding gene	Chr19:34943385-35012460 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025487	protein coding gene	Chr19:36465710-36537048 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022905	protein coding gene	Chr19:33123449-33190283 (+)
CAST/EiJ	MGP_CASTEiJ_G0024272	protein coding gene	Chr19:34751895-34826482 (+)
CBA/J	MGP_CBAJ_G0024782	protein coding gene	Chr19:38188017-38261813 (+)
DBA/2J	MGP_DBA2J_G0024914	protein coding gene	Chr19:33606065-33673535 (+)
FVB/NJ	MGP_FVBNJ_G0024875	protein coding gene	Chr19:33409459-33476749 (+)
LP/J	MGP_LPJ_G0025000	protein coding gene	Chr19:35525280-35593468 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024906	protein coding gene	Chr19:37994098-38095266 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025545	protein coding gene	Chr19:34962939-35033453 (+)
PWK/PhJ	MGP_PWKPhJ_G0024024	protein coding gene	Chr19:33428377-33498692 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023824	protein coding gene	Chr19:33803267-33878730 (+)
WSB/EiJ	MGP_WSBEiJ_G0024339	protein coding gene	Chr19:35067614-35138784 (+)

Human Ortholog

HECTD2, HECT domain E3 ubiquitin protein ligase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HECTD2, HECT domain E3 ubiquitin protein ligase 2
Links

HGNC:26736

NCBI Gene ID: 143279

neXtProt AC: NX_Q5U5R9

UniProt: Q5U5R9
Chr Location

10q23.32; chr10:91409235-91514829 (+) GRCh38

MGI Vertebrate Homology

Hectd2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HECTD2
Gene Tree

Hectd2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

7
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hectd2

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All Sequences

87
RefSeq

27
UniProt

7
CCDS

CCDS29773.1, CCDS50425.1

Ensembl

ENSMUSG00000041180 (Evidence)
NCBI Gene

226098

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041180	Ensembl Gene Model \| MGI Sequence Detail	66497	C57BL/6J	± kb
transcript	ENSMUST00000169036	Ensembl \| MGI Sequence Detail	3842	Not Applicable
polypeptide	ENSMUSP00000128387	Ensembl \| MGI Sequence Detail	775	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000031433 probable E3 ubiquitin-protein ligase HECTD2

(term hierarchy)
EC

2.3.2.26
InterPro Domains

IPR000569 HECT domain

IPR035983 HECT, E3 ligase catalytic domain

IPR044611 Ubiquitin-protein ligase E3A/B/C-like

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All nucleic 13

cDNA 12

Other 1

Microarray probesets 8

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MGI:2147718

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hectd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156192	Chr19:36532061-36532088 (+)	36 bp
Tssr156193	Chr19:36532090-36532114 (+)	63 bp
Tssr156194	Chr19:36532119-36532131 (+)	86 bp
Tssr156195	Chr19:36532142-36532173 (+)	119 bp
Tssr156196	Chr19:36532174-36532193 (+)	145 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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