Slc43a2 MGI Mouse Gene Detail - MGI:2442746 - solute carrier family 43, member 2

Symbol

Slc43a2
Name

solute carrier family 43, member 2
Synonyms

7630402D21Rik

Feature Type

protein coding gene
IDs

MGI:2442746
NCBI Gene: 215113
Alliance

gene page
Transcription Start Sites

24 TSS

Sequence Map

Chr11:75422520-75468401 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.92 cM
Mapping Data

1 experiment

SNPs within 2kb

983 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442746	protein coding gene	Chr11:75420741-75468401 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018717	protein coding gene	Chr11:76289800-76337822 (+)
A/J	MGP_AJ_G0018683	protein coding gene	Chr11:73448766-73495366 (+)
AKR/J	MGP_AKRJ_G0018653	protein coding gene	Chr11:75673357-75719179 (+)
BALB/cJ	MGP_BALBcJ_G0018657	protein coding gene	Chr11:73820896-73866707 (+)
C3H/HeJ	MGP_C3HHeJ_G0018470	protein coding gene	Chr11:75688160-75734747 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019108	protein coding gene	Chr11:78698275-78748745 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016743	protein coding gene	Chr11:70462635-70508998 (+)
CAST/EiJ	MGP_CASTEiJ_G0018024	protein coding gene	Chr11:76084385-76133980 (+)
CBA/J	MGP_CBAJ_G0018440	protein coding gene	Chr11:82137408-82191681 (+)
DBA/2J	MGP_DBA2J_G0018549	protein coding gene	Chr11:73052564-73098724 (+)
FVB/NJ	MGP_FVBNJ_G0018539	protein coding gene	Chr11:72613809-72660407 (+)
LP/J	MGP_LPJ_G0018620	protein coding gene	Chr11:76873115-76918949 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018565	protein coding gene	Chr11:82691837-82738854 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019148	protein coding gene	Chr11:75882106-75931700 (+)
PWK/PhJ	MGP_PWKPhJ_G0017795	protein coding gene	Chr11:73751142-73796287 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017586	protein coding gene	Chr11:75435099-75488227 (+)
WSB/EiJ	MGP_WSBEiJ_G0018077	protein coding gene	Chr11:75691635-75740483 (+)

Human Ortholog

SLC43A2, solute carrier family 43 member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC43A2, solute carrier family 43 member 2
Synonyms

LAT4
Links

HGNC:23087

NCBI Gene ID: 124935

neXtProt AC: NX_Q8N370

UniProt: Q8N370
Chr Location

17p13.3; chr17:1569254-1630088 (-) GRCh38

MGI Vertebrate Homology

Slc43a2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC43A2
Gene Tree

Slc43a2

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

9
Targeted

3
Genomic Mutations

2 involving Slc43a2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display fetal growth retardation, abnormal placental amino acid transport, slow postnatal weight gain, malnutrition and postnatal lethality, likely as a result of impaired intestinal amino acid absorption.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

838
Tissues

53
cDNA Data

70
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc43a2

ZFIN slc43a2a, slc43a2b

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All Sequences

94
RefSeq

31
UniProt

5
CCDS

CCDS25051.1

Ensembl

ENSMUSG00000038178 (Evidence)
NCBI Gene

215113

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038178	Ensembl Gene Model \| MGI Sequence Detail	45882	C57BL/6J	± kb
transcript	ENSMUST00000042561	Ensembl \| MGI Sequence Detail	6891	Not Applicable
polypeptide	ENSMUSP00000046074	Ensembl \| MGI Sequence Detail	568	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015142 large neutral amino acids transporter small subunit 4

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR036259 MFS transporter superfamily
GlyGen

Q8CGA3 1 site

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All nucleic 71

cDNA 70

Primer pair 1

Microarray probesets 5

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Slc43a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102966	Chr11:75422516-75422558 (+)	17 bp
Tssr102967	Chr11:75422832-75422852 (+)	322 bp
Tssr102968	Chr11:75422925-75422951 (+)	418 bp
Tssr102969	Chr11:75422953-75422977 (+)	445 bp
Tssr102970	Chr11:75422990-75423013 (+)	482 bp
Tssr102971	Chr11:75423022-75423046 (+)	514 bp
Tssr102972	Chr11:75423058-75423074 (+)	546 bp
Tssr102973	Chr11:75423094-75423106 (+)	580 bp
Tssr102974	Chr11:75424229-75424240 (+)	1,715 bp
Tssr102975	Chr11:75424281-75424356 (+)	1,799 bp
Tssr102977	Chr11:75454479-75454492 (+)	31,966 bp
Tssr102978	Chr11:75457685-75457701 (+)	35,173 bp
Tssr102979	Chr11:75458805-75458819 (+)	36,292 bp
Tssr102980	Chr11:75463285-75463311 (+)	40,778 bp
Tssr102981	Chr11:75463338-75463371 (+)	40,835 bp
Tssr102982	Chr11:75463545-75463561 (+)	41,033 bp
Tssr102983	Chr11:75463572-75463617 (+)	41,075 bp
Tssr102984	Chr11:75463638-75463650 (+)	41,124 bp
Tssr102985	Chr11:75467598-75467612 (+)	45,085 bp
Tssr102986	Chr11:75467716-75467735 (+)	45,206 bp
Tssr102987	Chr11:75467763-75467776 (+)	45,250 bp
Tssr102988	Chr11:75467842-75467871 (+)	45,337 bp
Tssr102989	Chr11:75467916-75467950 (+)	45,413 bp
Tssr102990	Chr11:75467953-75467964 (+)	45,439 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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