Katnip MGI Mouse Gene Detail - MGI:2442760 - katanin interacting protein

Symbol

Katnip
Name

katanin interacting protein
Synonyms

D430042O09Rik

Feature Type

protein coding gene
IDs

MGI:2442760
NCBI Gene: 233865
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:125307060-125473965 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.01 cM
Mapping Data

1 experiment

SNPs within 2kb

3545 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442760	protein coding gene	Chr7:125307027-125473967 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032971	protein coding gene	Chr7:129927295-130100749 (+)
A/J	MGP_AJ_G0032954	protein coding gene	Chr7:126520641-126690523 (+)
AKR/J	MGP_AKRJ_G0032886	protein coding gene	Chr7:129716370-129884209 (+)
BALB/cJ	MGP_BALBcJ_G0032959	protein coding gene	Chr7:126177203-126343924 (+)
C3H/HeJ	MGP_C3HHeJ_G0032669	protein coding gene	Chr7:129640862-129807080 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033465	protein coding gene	Chr7:135006512-135180382 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030437	protein coding gene	Chr7:127720918-127890840 (+)
CAST/EiJ	MGP_CASTEiJ_G0031997	protein coding gene	Chr7:121430765-121645551 (+)
CBA/J	MGP_CBAJ_G0032642	protein coding gene	Chr7:139543551-139715882 (+)
DBA/2J	MGP_DBA2J_G0032794	protein coding gene	Chr7:124499046-124666054 (+)
FVB/NJ	MGP_FVBNJ_G0032747	protein coding gene	Chr7:124334296-124508807 (+)
LP/J	MGP_LPJ_G0032888	protein coding gene	Chr7:131395730-131567087 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032779	protein coding gene	Chr7:140776029-140948035 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033485	protein coding gene	Chr7:128718531-128888020 (+)
PWK/PhJ	MGP_PWKPhJ_G0031705	protein coding gene	Chr7:117478537-117688127 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031551	protein coding gene	Chr7:115538832-115711800 (+)
WSB/EiJ	MGP_WSBEiJ_G0032110	protein coding gene	Chr7:129689009-129862153 (+)

Human Ortholog

KATNIP, katanin interacting protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KATNIP, katanin interacting protein
Synonyms

JBTS26, KIAA0556
Links

HGNC:29068

NCBI Gene ID: 23247

neXtProt AC: NX_O60303

UniProt: O60303
Chr Location

16p12.1; chr16:27550133-27780344 (+) GRCh38

MGI Vertebrate Homology

Katnip stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KATNIP
Gene Tree

Katnip

Diseases

1 with Katnip mouse models; 1 with human KATNIP associations

Human Disease

Mouse Models

Joubert syndrome 26

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

4
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit variable obstructive hydrocephaly and enlarged lateral ventricles resulting from a blockage of cerebrospinal fluid flow in the cerebral aqueduct but show no gross defects in ventricular ependymal cilium structure or motility.

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All GO Annotations

5
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

5
cDNA Data

44
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

65
RefSeq

19
UniProt

5
CCDS

CCDS40123.1, CCDS90326.1

Ensembl

ENSMUSG00000032743 (Evidence)
NCBI Gene

233865

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032743	Ensembl Gene Model \| MGI Sequence Detail	166906	C57BL/6J	± kb
transcript	ENSMUST00000069660	Ensembl \| MGI Sequence Detail	6148	Not Applicable
polypeptide	ENSMUSP00000065744	Ensembl \| MGI Sequence Detail	1610	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000059748 katanin-interacting protein

(term hierarchy)
InterPro Domains

IPR026704 Katanin-interacting protein

IPR027859 KATNIP domain

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All nucleic 45

cDNA 45

Microarray probesets 11

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MGI:6449852

Summaries

All 29

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Katnip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68994	Chr7:125307065-125307101 (+)	23 bp
Tssr68995	Chr7:125307117-125307130 (+)	64 bp
Tssr68996	Chr7:125352900-125352910 (+)	45,845 bp
Tssr68997	Chr7:125428701-125428720 (+)	121,651 bp
Tssr68998	Chr7:125428825-125428840 (+)	121,773 bp
Tssr68999	Chr7:125471849-125471892 (+)	164,811 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24