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Trim65 Gene Detail
Summary
  • Symbol
    Trim65
  • Name
    tripartite motif-containing 65
  • Synonyms
    4732463G12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442815
    NCBI Gene: 338364
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116012672-116021954 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    357 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442815
 protein coding gene Chr11:116008015-116022239 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019415
 protein coding gene Chr11:120211008-120220680 (-)
A/J MGP_AJ_G0019384
 protein coding gene Chr11:114958940-114968462 (-)
AKR/J MGP_AKRJ_G0019354
 protein coding gene Chr11:118385775-118395099 (-)
BALB/cJ MGP_BALBcJ_G0019358
 protein coding gene Chr11:115369540-115378864 (-)
C3H/HeJ MGP_C3HHeJ_G0019164
 protein coding gene Chr11:118740007-118749279 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019808
 protein coding gene Chr11:123893788-123907681 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017431
 protein coding gene Chr11:111973030-111981933 (-)
CAST/EiJ MGP_CASTEiJ_G0018719
 protein coding gene Chr11:120094898-120104181 (-)
CBA/J MGP_CBAJ_G0019136
 protein coding gene Chr11:128784005-128793282 (-)
DBA/2J MGP_DBA2J_G0019247
 protein coding gene Chr11:114375099-114384562 (-)
FVB/NJ MGP_FVBNJ_G0019239
 protein coding gene Chr11:113890104-113899573 (-)
LP/J MGP_LPJ_G0019317
 protein coding gene Chr11:120592311-120601615 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019272
 protein coding gene Chr11:127874331-127883838 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019846
 protein coding gene Chr11:119045619-119055642 (-)
PWK/PhJ MGP_PWKPhJ_G0018483
 protein coding gene Chr11:115711869-115721470 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018276
 protein coding gene Chr11:118799194-118808369 (-)
WSB/EiJ MGP_WSBEiJ_G0018771
 protein coding gene Chr11:119008624-119018558 (-)



Homology
more
  • Human Ortholog
    TRIM65, tripartite motif containing 65
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM65, tripartite motif containing 65
  • Synonyms
    4732463G12Rik
  • Links
    NCBI Gene ID: 201292
    neXtProt AC: NX_Q6PJ69
    UniProt: Q6PJ69

  • Chr Location
    17q25.1; chr17:75879537-75896951 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to Picornaviridae infection and associated morbidity/mortality, with markedly decreased circulating type I interferon levels following infection with encephalomyocarditis virus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054517 Ensembl Gene Model | MGI Sequence Detail 9283 C57BL/6J ±  kb
    transcript ENSMUST00000067632 Ensembl | MGI Sequence Detail 3048 Not Applicable  
    polypeptide ENSMUSP00000063410 Ensembl | MGI Sequence Detail 522 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345645 Huang Y, et al., E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis. Cell Death Dis. 2024 Jan 11;15(1):29
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory