Cobll1 MGI Mouse Gene Detail - MGI:2442894

Symbol

Cobll1
Name

Cobl-like 1
Synonyms

Coblr1, D430044D16Rik

Feature Type

protein coding gene
IDs

MGI:2442894
NCBI Gene: 319876
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:64918683-65069742 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 38.35 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

4669 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442894	protein coding gene	Chr2:64918683-65069747 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025777	protein coding gene	Chr2:64870662-65029401 (-)
A/J	MGP_AJ_G0025753	protein coding gene	Chr2:62381781-62532325 (-)
AKR/J	MGP_AKRJ_G0025723	protein coding gene	Chr2:64048779-64200018 (-)
BALB/cJ	MGP_BALBcJ_G0025748	protein coding gene	Chr2:62527908-62679966 (-)
C3H/HeJ	MGP_C3HHeJ_G0025509	protein coding gene	Chr2:64206627-64367793 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026195	protein coding gene	Chr2:66778173-66949620 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023599	protein coding gene	Chr2:59745411-59900575 (-)
CAST/EiJ	MGP_CASTEiJ_G0024973	protein coding gene	Chr2:64250140-64414290 (-)
CBA/J	MGP_CBAJ_G0025489	protein coding gene	Chr2:69326187-69483125 (-)
DBA/2J	MGP_DBA2J_G0025620	protein coding gene	Chr2:62003276-62154770 (-)
FVB/NJ	MGP_FVBNJ_G0025582	protein coding gene	Chr2:61424781-61576569 (-)
LP/J	MGP_LPJ_G0025708	protein coding gene	Chr2:64689112-64845990 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025613	protein coding gene	Chr2:71264235-71429276 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026252	protein coding gene	Chr2:64104440-64257381 (-)
PWK/PhJ	MGP_PWKPhJ_G0024714	protein coding gene	Chr2:61822249-61976342 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024521	protein coding gene	Chr2:64246566-64418866 (-)
WSB/EiJ	MGP_WSBEiJ_G0025041	protein coding gene	Chr2:64461988-64620947 (-)

Human Ortholog

COBLL1, cordon-bleu WH2 repeat protein like 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COBLL1, cordon-bleu WH2 repeat protein like 1
Synonyms

COBLR1
Links

HGNC:23571

NCBI Gene ID: 22837

neXtProt AC: NX_Q53SF7

UniProt: Q53SF7
Chr Location

2q24.3; chr2:164653624-164843679 (-) GRCh38

MGI Vertebrate Homology

Cobll1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: COBLL1
Gene Tree

Cobll1

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

1
Genomic Mutations

1 involving Cobll1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

776
Tissues

27
cDNA Data

81
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cobll1

ZFIN cobll1b

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All Sequences

114
RefSeq

54
UniProt

7
CCDS

CCDS16072.1, CCDS50595.1, CCDS89492.1

Ensembl

ENSMUSG00000034903 (Evidence)
NCBI Gene

319876

			Length	Strain/Species	Flank
genomic	319876	NCBI Gene Model \| MGI Sequence Detail	151060	C57BL/6J	± kb
transcript	NM_001363076	RefSeq \| MGI Sequence Detail	5306	C57BL/6
polypeptide	Q3UMF0	UniProt \| EBI \| MGI Sequence Detail	1273	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000005681 cordon-bleu protein-like 1

(term hierarchy)
InterPro Domains

IPR019025 Cordon-bleu, ubiquitin-like domain

IPR039895 Protein cordon-bleu-like
GlyGen

Q3UMF0 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 82

cDNA 81

Primer pair 1

Microarray probesets 3

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MGI:1917072

Summaries

All 28

Developmental Gene Expression 3

Gene Ontology 1

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cobll1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24359	Chr2:65069585-65069606 (-)	146 bp
Tssr24358	Chr2:65069436-65069469 (-)	289 bp
Tssr24357	Chr2:65069383-65069402 (-)	349 bp
Tssr24356	Chr2:65069129-65069140 (-)	607 bp
Tssr24355	Chr2:65068969-65068987 (-)	764 bp
Tssr24354	Chr2:65068937-65068953 (-)	797 bp
Tssr24353	Chr2:65068847-65068874 (-)	881 bp
Tssr24352	Chr2:65068785-65068841 (-)	929 bp
Tssr24351	Chr2:65068131-65068136 (-)	1,608 bp
Tssr24350	Chr2:65042327-65042332 (-)	27,412 bp
Tssr24349	Chr2:65019524-65019528 (-)	50,216 bp
Tssr24348	Chr2:65019081-65019118 (-)	50,642 bp
Tssr24347	Chr2:65002139-65002153 (-)	67,596 bp
Tssr24346	Chr2:65002008-65002029 (-)	67,723 bp
Tssr24345	Chr2:64920782-64920785 (-)	148,958 bp
Tssr24344	Chr2:64919532-64919534 (-)	150,209 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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