Niban2 MGI Mouse Gene Detail - MGI:2442910 - niban apoptosis regulator 2

Symbol

Niban2
Name

niban apoptosis regulator 2
Synonyms

9130404D14Rik, Fam129b

Feature Type

protein coding gene
IDs

MGI:2442910
NCBI Gene: 227737
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr2:32766146-32815265 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 22.09 cM
Mapping Data

1 experiment

SNPs within 2kb

1260 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442910	protein coding gene	Chr2:32766126-32815266 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025626	protein coding gene	Chr2:31377469-31427667 (+)
A/J	MGP_AJ_G0025603	protein coding gene	Chr2:30033724-30082799 (+)
AKR/J	MGP_AKRJ_G0025573	protein coding gene	Chr2:31112694-31161832 (+)
BALB/cJ	MGP_BALBcJ_G0025600	protein coding gene	Chr2:30153727-30202962 (+)
C3H/HeJ	MGP_C3HHeJ_G0025360	protein coding gene	Chr2:30993938-31046319 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026044	protein coding gene	Chr2:32321425-32371643 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023453	protein coding gene	Chr2:28759231-28809284 (+)
CAST/EiJ	MGP_CASTEiJ_G0024822	protein coding gene	Chr2:30953176-31005405 (+)
CBA/J	MGP_CBAJ_G0025338	protein coding gene	Chr2:33558254-33611883 (+)
DBA/2J	MGP_DBA2J_G0025471	protein coding gene	Chr2:29798101-29847570 (+)
FVB/NJ	MGP_FVBNJ_G0025433	protein coding gene	Chr2:29685703-29735524 (+)
LP/J	MGP_LPJ_G0025557	protein coding gene	Chr2:31254441-31307207 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025464	protein coding gene	Chr2:33158904-33211826 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026102	protein coding gene	Chr2:30983732-31036329 (+)
PWK/PhJ	MGP_PWKPhJ_G0024570	protein coding gene	Chr2:29707914-29758459 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024370	protein coding gene	Chr2:31140652-31190944 (+)
WSB/EiJ	MGP_WSBEiJ_G0024891	protein coding gene	Chr2:31171995-31222970 (+)

Human Ortholog

NIBAN2, niban apoptosis regulator 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NIBAN2, niban apoptosis regulator 2
Synonyms

bA356B19.6, C9orf88, FAM129B, MEG-3, MINERVA, OC58
Links

HGNC:25282

NCBI Gene ID: 64855

neXtProt AC: NX_Q96TA1

UniProt: Q96TA1
Chr Location

9q34.11; chr9:127505339-127579031 (-) GRCh38

MGI Vertebrate Homology

Niban2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NIBAN2
Gene Tree

Niban2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

54
Endonuclease-mediated

1
Gene trapped

51
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available

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All GO Annotations

25
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

164

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase niban2

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All Sequences

65
RefSeq

2
UniProt

2
CCDS

CCDS15934.1

Ensembl

ENSMUSG00000026796 (Evidence)
NCBI Gene

227737

			Length	Strain/Species	Flank
genomic	227737	NCBI Gene Model \| MGI Sequence Detail	49120	C57BL/6J	± kb
transcript	NM_146119	RefSeq \| MGI Sequence Detail	3693	C57BL/6
polypeptide	Q8R1F1	UniProt \| EBI \| MGI Sequence Detail	749	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031630 protein Niban 2

(term hierarchy)
InterPro Domains

IPR026088 Niban-like

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 164

cDNA 164

Microarray probesets 4

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MGI:6393850

Summaries

All 29

Gene Ontology 4

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:175321 Chen S, et al., FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells. J Biol Chem. 2011 Mar 25;286(12):10201-9

TSS for Niban2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17357	Chr2:32765867-32765887 (+)	-269 bp
Tssr17358	Chr2:32766148-32766253 (+)	55 bp
Tssr17359	Chr2:32767960-32767990 (+)	1,829 bp
Tssr17360	Chr2:32768055-32768063 (+)	1,913 bp
Tssr17362	Chr2:32784570-32784575 (+)	18,427 bp
Tssr17363	Chr2:32787888-32787895 (+)	21,746 bp
Tssr17364	Chr2:32791809-32791858 (+)	25,688 bp
Tssr17365	Chr2:32801394-32801417 (+)	35,260 bp
Tssr17366	Chr2:32802490-32802530 (+)	36,364 bp
Tssr17367	Chr2:32806421-32806431 (+)	40,280 bp
Tssr17368	Chr2:32806465-32806494 (+)	40,334 bp
Tssr17369	Chr2:32806543-32806550 (+)	40,401 bp
Tssr17370	Chr2:32806594-32806640 (+)	40,471 bp
Tssr17371	Chr2:32806651-32806671 (+)	40,515 bp
Tssr17372	Chr2:32814517-32814539 (+)	48,382 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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