Slc41a2 MGI Mouse Gene Detail - MGI:2442940 - solute carrier family 41, member 2

Symbol

Slc41a2
Name

solute carrier family 41, member 2
Synonyms

A230035L05Rik

Feature Type

protein coding gene
IDs

MGI:2442940
NCBI Gene: 338365
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:83066712-83173746 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 41.03 cM
Mapping Data

1 experiment

SNPs within 2kb

3131 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442940	protein coding gene	Chr10:83066712-83174657 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017584	protein coding gene	Chr10:84014547-84138021 (-)
A/J	MGP_AJ_G0017564	protein coding gene	Chr10:81172342-81280624 (-)
AKR/J	MGP_AKRJ_G0017523	protein coding gene	Chr10:83427453-83544027 (-)
BALB/cJ	MGP_BALBcJ_G0017527	protein coding gene	Chr10:81445813-81553057 (-)
C3H/HeJ	MGP_C3HHeJ_G0017349	protein coding gene	Chr10:83511309-83631356 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017984	protein coding gene	Chr10:86945293-87054970 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015668	protein coding gene	Chr10:76905438-77008803 (-)
CAST/EiJ	MGP_CASTEiJ_G0016916	protein coding gene	Chr10:83442803-83560822 (-)
CBA/J	MGP_CBAJ_G0017319	protein coding gene	Chr10:90529289-90652649 (-)
DBA/2J	MGP_DBA2J_G0017425	protein coding gene	Chr10:80340897-80449030 (-)
FVB/NJ	MGP_FVBNJ_G0017419	protein coding gene	Chr10:79579966-79689079 (-)
LP/J	MGP_LPJ_G0017497	protein coding gene	Chr10:84655846-84775678 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017447	protein coding gene	Chr10:92167370-92287696 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018021	protein coding gene	Chr10:83369070-83483342 (-)
PWK/PhJ	MGP_PWKPhJ_G0016697	protein coding gene	Chr10:80225243-80335296 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016487	protein coding gene	Chr10:82049486-82162776 (-)
WSB/EiJ	MGP_WSBEiJ_G0016975	protein coding gene	Chr10:83400711-83516242 (-)

Human Ortholog

SLC41A2, solute carrier family 41 member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC41A2, solute carrier family 41 member 2
Synonyms

SLC41A1-L1
Links

HGNC:31045

NCBI Gene ID: 84102

neXtProt AC: NX_Q96JW4

UniProt: Q96JW4
Chr Location

12q23.3; chr12:104801801-104958746 (-) GRCh38

MGI Vertebrate Homology

Slc41a2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC41A2
Gene Tree

Slc41a2

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

1 involving Slc41a2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available

less

All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

15
cDNA Data

26
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc41a2

less

All Sequences

43
RefSeq

4
UniProt

5
CCDS

CCDS24075.1

Ensembl

ENSMUSG00000034591 (Evidence)
NCBI Gene

338365

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034591	Ensembl Gene Model \| MGI Sequence Detail	107035	C57BL/6J	± kb
transcript	ENSMUST00000039956	Ensembl \| MGI Sequence Detail	4742	Not Applicable
polypeptide	ENSMUSP00000036690	Ensembl \| MGI Sequence Detail	573	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000015140 solute carrier family 41 member 2

(term hierarchy)
InterPro Domains

IPR045349 SLC41A divalent cation transporter

IPR036739 SLC41A/MgtE divalent cation transporters, integral membrane domain superfamily

IPR006667 SLC41A/MgtE, integral membrane domain

less

All nucleic 27

cDNA 26

Primer pair 1

Microarray probesets 2

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc41a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98699	Chr10:83173709-83173744 (-)	19 bp
Tssr98698	Chr10:83173674-83173697 (-)	60 bp
Tssr98697	Chr10:83173347-83173396 (-)	374 bp
Tssr98696	Chr10:83173286-83173311 (-)	447 bp
Tssr98695	Chr10:83173263-83173278 (-)	475 bp
Tssr98694	Chr10:83162579-83162621 (-)	11,146 bp
Tssr98693	Chr10:83158756-83158776 (-)	14,980 bp
Tssr98692	Chr10:83152597-83152601 (-)	21,147 bp
Tssr98691	Chr10:83075208-83075245 (-)	98,519 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24