Gramd1c MGI Mouse Gene Detail - MGI:2443024

Symbol

Gramd1c
Name

GRAM domain containing 1C
Synonyms

4921521N14Rik

Feature Type

protein coding gene
IDs

MGI:2443024
NCBI Gene: 207798
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr16:43800713-43883708 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 28.44 cM
Mapping Data

1 experiment

SNPs within 2kb

2112 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443024	protein coding gene	Chr16:43800713-43883757 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022833	protein coding gene	Chr16:42698171-42768525 (-)
A/J	MGP_AJ_G0022798	protein coding gene	Chr16:40778838-40839627 (-)
AKR/J	MGP_AKRJ_G0022770	protein coding gene	Chr16:42095947-42146305 (-)
BALB/cJ	MGP_BALBcJ_G0022799	protein coding gene	Chr16:40769998-40820058 (-)
C3H/HeJ	MGP_C3HHeJ_G0022563	protein coding gene	Chr16:42281029-42333316 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023246	protein coding gene	Chr16:43691551-43746103 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020761	protein coding gene	Chr16:40841344-40917069 (-)
CAST/EiJ	MGP_CASTEiJ_G0022089	protein coding gene	Chr16:42486635-42543905 (-)
CBA/J	MGP_CBAJ_G0022534	protein coding gene	Chr16:45532968-45588149 (-)
DBA/2J	MGP_DBA2J_G0022666	protein coding gene	Chr16:40512775-40563468 (-)
FVB/NJ	MGP_FVBNJ_G0022641	protein coding gene	Chr16:40487864-40539154 (-)
LP/J	MGP_LPJ_G0022734	protein coding gene	Chr16:42415285-42470268 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022660	protein coding gene	Chr16:44933070-44996243 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023261	protein coding gene	Chr16:42114701-42179549 (-)
PWK/PhJ	MGP_PWKPhJ_G0021829	protein coding gene	Chr16:40905715-40991341 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021660	protein coding gene	Chr16:42011742-42097306 (-)
WSB/EiJ	MGP_WSBEiJ_G0022133	protein coding gene	Chr16:42212478-42273738 (-)

Human Ortholog

GRAMD1C, GRAM domain containing 1C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRAMD1C, GRAM domain containing 1C
Links

HGNC:25252

NCBI Gene ID: 54762

neXtProt AC: NX_Q8IYS0

UniProt: Q8IYS0
Chr Location

3q13.31; chr3:113828182-113947174 (+) GRCh38

MGI Vertebrate Homology

Gramd1c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GRAMD1C
Gene Tree

Gramd1c

less

Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and exhibit normal body weight and no significant changes in plasma, liver, or fecal levels of cholesterol and various plant and animal-derived sterols under divergent dietary cholesterol conditions, but do show decreased deoxycholic acid and increased plasma cortisol levels under low dietary cholesterol.

less

All GO Annotations

13
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

27
cDNA Data

6
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gramd1c

ZFIN gramd1c

less

All Sequences

54
RefSeq

16
UniProt

2
CCDS

CCDS28181.1

Ensembl

ENSMUSG00000036292 (Evidence)
NCBI Gene

207798

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036292	Ensembl Gene Model \| MGI Sequence Detail	82996	C57BL/6J	± kb
transcript	ENSMUST00000214098	Ensembl \| MGI Sequence Detail	2046	Not Applicable
polypeptide	ENSMUSP00000150056	Ensembl \| MGI Sequence Detail	662	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000032711 protein Aster-C

(term hierarchy)
PDB

7AZN, 8AXW
InterPro Domains

IPR051482 Cholesterol transport domain-containing protein

IPR004182 GRAM domain

IPR011993 PH-like domain superfamily

IPR031968 VASt domain

less

All nucleic 6

cDNA 6

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:347902 Banerjee R, et al., The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance. Front Physiol. 2024;15:1371096

TSS for Gramd1c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141163	Chr16:43881856-43881869 (-)	1,845 bp
Tssr141162	Chr16:43881844-43881847 (-)	1,862 bp
Tssr141161	Chr16:43881832-43881842 (-)	1,871 bp
Tssr141160	Chr16:43848346-43848359 (-)	35,355 bp
Tssr141159	Chr16:43848301-43848332 (-)	35,391 bp
Tssr141158	Chr16:43848295-43848300 (-)	35,410 bp
Tssr141157	Chr16:43836750-43836762 (-)	46,952 bp
Tssr141156	Chr16:43836682-43836747 (-)	46,993 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24