Arid5a MGI Mouse Gene Detail - MGI:2443039 - AT-rich interaction domain 5A

Symbol

Arid5a
Name

AT-rich interaction domain 5A
Synonyms

D430024K22Rik, Mrf1

Feature Type

protein coding gene
IDs

MGI:2443039
NCBI Gene: 214855
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:36346814-36363110 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.20 cM
Mapping Data

1 experiment

SNPs within 2kb

495 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443039	protein coding gene	Chr1:36346814-36363117 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015920	protein coding gene	Chr1:34830417-34846728 (+)
A/J	MGP_AJ_G0015904	protein coding gene	Chr1:33900088-33916370 (+)
AKR/J	MGP_AKRJ_G0015859	protein coding gene	Chr1:34386296-34402590 (+)
BALB/cJ	MGP_BALBcJ_G0015858	protein coding gene	Chr1:33592182-33608486 (+)
C3H/HeJ	MGP_C3HHeJ_G0015691	protein coding gene	Chr1:34565416-34581699 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016311	protein coding gene	Chr1:36408469-36425844 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014033	protein coding gene	Chr1:30954262-30970696 (+)
CAST/EiJ	MGP_CASTEiJ_G0015272	protein coding gene	Chr1:34456969-34473497 (+)
CBA/J	MGP_CBAJ_G0015663	protein coding gene	Chr1:37372317-37391287 (+)
DBA/2J	MGP_DBA2J_G0015764	protein coding gene	Chr1:33238768-33255062 (+)
FVB/NJ	MGP_FVBNJ_G0015766	protein coding gene	Chr1:32755759-32772054 (+)
LP/J	MGP_LPJ_G0015834	protein coding gene	Chr1:35200035-35216853 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015786	protein coding gene	Chr1:39607301-39623592 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016358	protein coding gene	Chr1:34405119-34421413 (+)
PWK/PhJ	MGP_PWKPhJ_G0015055	protein coding gene	Chr1:32983902-33000129 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014837	protein coding gene	Chr1:34362980-34379269 (+)
WSB/EiJ	MGP_WSBEiJ_G0015334	protein coding gene	Chr1:34362423-34378714 (+)

Human Ortholog

ARID5A, AT-rich interaction domain 5A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARID5A, AT-rich interaction domain 5A
Synonyms

MRF-1, MRF1, RP11-363D14
Links

HGNC:17361

NCBI Gene ID: 10865

neXtProt AC: NX_Q03989

UniProt: Q03989
Chr Location

2q11.2; chr2:96536743-96552638 (+) GRCh38

MGI Vertebrate Homology

Arid5a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARID5A
Gene Tree

Arid5a

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

7
Targeted

3
Genomic Mutations

1 involving Arid5a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced serum interleukin-6 and tumor necrosis factor levels following LPS treatment, and decreased susceptibility to experimental autoimmune encephalomyelitis along with decreased T-helper 17 cell number and increased IFN-gamma producing T cell number.

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All GO Annotations

46
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

844
Tissues

101
cDNA Data

58
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

79
RefSeq

13
UniProt

5
CCDS

CCDS14876.1, CCDS48239.1, CCDS69878.1, CCDS78560.1

Ensembl

ENSMUSG00000037447 (Evidence)
NCBI Gene

214855

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037447	Ensembl Gene Model \| MGI Sequence Detail	16297	C57BL/6J	± kb
transcript	ENSMUST00000115031	Ensembl \| MGI Sequence Detail	3002	Not Applicable
polypeptide	ENSMUSP00000110683	Ensembl \| MGI Sequence Detail	684	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004269 AT-rich interactive domain-containing protein 5A

(term hierarchy)
InterPro Domains

IPR001606 ARID DNA-binding domain

IPR036431 ARID DNA-binding domain superfamily

IPR051232 AT-rich Interactive Domain/SWI1 Chromatin Remodeling

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All nucleic 59

cDNA 58

Primer pair 1

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 15
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7

TSS for Arid5a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6253	Chr1:36346808-36346816 (+)	-2 bp
Tssr6254	Chr1:36346826-36346844 (+)	21 bp
Tssr6255	Chr1:36346855-36346860 (+)	44 bp
Tssr6256	Chr1:36347140-36347156 (+)	334 bp
Tssr6257	Chr1:36347218-36347230 (+)	410 bp
Tssr6258	Chr1:36347348-36347362 (+)	541 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24