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Plekhs1 Gene Detail
Summary
  • Symbol
    Plekhs1
  • Name
    pleckstrin homology domain containing, family S member 1
  • Synonyms
    9930023K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443041
    NCBI Gene: 226245
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56450072-56475184 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 51.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    893 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443041
 protein coding gene Chr19:56445705-56475184 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025264
 protein coding gene Chr19:56812543-56837644 (+)
A/J MGP_AJ_G0025240
 protein coding gene Chr19:54002746-54027919 (+)
AKR/J MGP_AKRJ_G0025209
 protein coding gene Chr19:55706848-55734044 (+)
BALB/cJ MGP_BALBcJ_G0025235
 protein coding gene Chr19:54086520-54112190 (+)
C3H/HeJ MGP_C3HHeJ_G0024995
 protein coding gene Chr19:55943756-55974820 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025678
 protein coding gene Chr19:58173132-58198227 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023090
 protein coding gene Chr19:52931462-52957782 (+)
CAST/EiJ MGP_CASTEiJ_G0024460
 protein coding gene Chr19:55951088-55989597 (+)
CBA/J MGP_CBAJ_G0024975
 protein coding gene Chr19:61059706-61087805 (+)
DBA/2J MGP_DBA2J_G0025107
 protein coding gene Chr19:53795027-53820503 (+)
FVB/NJ MGP_FVBNJ_G0025068
 protein coding gene Chr19:53496701-53521784 (+)
LP/J MGP_LPJ_G0025193
 protein coding gene Chr19:56671873-56696971 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025101
 protein coding gene Chr19:60357118-60382252 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025736
 protein coding gene Chr19:55916983-55942071 (+)
PWK/PhJ MGP_PWKPhJ_G0024208
 protein coding gene Chr19:53748766-53775743 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024011
 protein coding gene Chr19:54594342-54620399 (+)
WSB/EiJ MGP_WSBEiJ_G0024530
 protein coding gene Chr19:56058558-56084859 (+)



Homology
more
  • Human Ortholog
    PLEKHS1, pleckstrin homology domain containing S1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHS1, pleckstrin homology domain containing S1
  • Synonyms
    C10orf81, HEL185
  • Links
    NCBI Gene ID: 79949
    neXtProt AC: NX_Q5SXH7
    UniProt: Q5SXH7

  • Chr Location
    10q25.3; chr10:113751262-113783429 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    29
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035818 Ensembl Gene Model | MGI Sequence Detail 25113 C57BL/6J ±  kb
transcript ENSMUST00000039666 Ensembl | MGI Sequence Detail 2378 Not Applicable  
polypeptide ENSMUSP00000035440 Ensembl | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030967 pleckstrin homology domain-containing family S member 1
    (term hierarchy)
  • InterPro Domains
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR042986 Pleckstrin homology domain-containing family S member 1
Molecular
Reagents
less
  • All nucleic 29
    cDNA 29

    Microarray probesets 2
References
more
  • Summaries
    All 17
    Phenotypes 1
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:339309 Chessa TAM, et al., PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Mol Cell. 2023 Aug 17;83(16):2991-3009.e13
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory