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Agps Gene Detail
Summary
  • Symbol
    Agps
  • Name
    alkylglycerone phosphate synthase
  • Synonyms
    9930035G10Rik, ADAPS, bs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443065
    NCBI Gene: 228061
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:75662521-75761694 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443065
 protein coding gene Chr2:75662477-75761694 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025859
 protein coding gene Chr2:76214134-76318597 (+)
A/J MGP_AJ_G0025836
 protein coding gene Chr2:73226688-73325748 (+)
AKR/J MGP_AKRJ_G0025804
 protein coding gene Chr2:75203246-75304269 (+)
BALB/cJ MGP_BALBcJ_G0025830
 protein coding gene Chr2:73414076-73513137 (+)
C3H/HeJ MGP_C3HHeJ_G0025590
 protein coding gene Chr2:75408572-75517402 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026277
 protein coding gene Chr2:78480675-78581451 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023680
 protein coding gene Chr2:70644606-70744684 (+)
CAST/EiJ MGP_CASTEiJ_G0025054
 protein coding gene Chr2:75731663-75838079 (+)
CBA/J MGP_CBAJ_G0025571
 protein coding gene Chr2:81359029-81468761 (+)
DBA/2J MGP_DBA2J_G0025702
 protein coding gene Chr2:72822469-72921421 (+)
FVB/NJ MGP_FVBNJ_G0025664
 protein coding gene Chr2:72208997-72307163 (+)
LP/J MGP_LPJ_G0025790
 protein coding gene Chr2:76063972-76174265 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025695
 protein coding gene Chr2:83231120-83342572 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026334
 protein coding gene Chr2:75340585-75443078 (+)
PWK/PhJ MGP_PWKPhJ_G0024795
 protein coding gene Chr2:72781572-72883018 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024603
 protein coding gene Chr2:75566997-75671447 (+)
WSB/EiJ MGP_WSBEiJ_G0025122
 protein coding gene Chr2:75787586-75893234 (+)



Homology
more
  • Human Ortholog
    AGPS, alkylglycerone phosphate synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGPS, alkylglycerone phosphate synthase
  • Synonyms
    ADAP-S, ADAS, ADHAPS, ADPS, ALDHPSY, RCDP3
  • Links
    NCBI Gene ID: 8540
    neXtProt AC: NX_O00116
    UniProt: O00116

  • Chr Location
    2q31.2; chr2:177392746-177567024 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Agps mouse models; 2 with human AGPS associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele exhibit male infertility, azoospermia, microphthalmia, and cataracts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    101
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042410 Ensembl Gene Model | MGI Sequence Detail 99174 C57BL/6J ±  kb
    transcript ENSMUST00000047232 Ensembl | MGI Sequence Detail 7359 Not Applicable  
    polypeptide ENSMUSP00000041967 Ensembl | MGI Sequence Detail 671 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000003842 alkyldihydroxyacetonephosphate synthase, peroxisomal
      (term hierarchy)
    • EC
      2.5.1.26
    • InterPro Domains
      IPR025650 Alkyldihydroxyacetonephosphate synthase
      IPR016166 FAD-binding domain, PCMH-type
      IPR004113 FAD-binding oxidoreductase/transferase, type 4, C-terminal
      IPR036318 FAD-binding, type PCMH-like superfamily
      IPR016167 FAD-binding, type PCMH, subdomain 1
      IPR016169 FAD-binding, type PCMH, subdomain 2
      IPR016164 FAD-linked oxidase-like, C-terminal
      IPR006094 FAD linked oxidase, N-terminal
      IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139316, MGI:3777321
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:269738 Guerreiro I, et al., Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan. Elife. 2016 Aug 1;5:e16087
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory