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Cpeb3 Gene Detail
Summary
  • Symbol
    Cpeb3
  • Name
    cytoplasmic polyadenylation element binding protein 3
  • Synonyms
    4831444O18Rik, mKIAA0940
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443075
    NCBI Gene: 208922
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:36998691-37186000 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4458 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443075
 protein coding gene Chr19:36996742-37186000 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025077
 protein coding gene Chr19:35949326-36149665 (-)
A/J MGP_AJ_G0025053
 protein coding gene Chr19:34221456-34408991 (-)
AKR/J MGP_AKRJ_G0025021
 protein coding gene Chr19:35386426-35587455 (-)
BALB/cJ MGP_BALBcJ_G0025051
 protein coding gene Chr19:34306251-34495552 (-)
C3H/HeJ MGP_C3HHeJ_G0024810
 protein coding gene Chr19:35439901-35638422 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025492
 protein coding gene Chr19:36983673-37205189 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022910
 protein coding gene Chr19:33582400-33768830 (-)
CAST/EiJ MGP_CASTEiJ_G0024277
 protein coding gene Chr19:35275571-35479659 (-)
CBA/J MGP_CBAJ_G0024787
 protein coding gene Chr19:38731498-38936295 (-)
DBA/2J MGP_DBA2J_G0024919
 protein coding gene Chr19:34077676-34266312 (-)
FVB/NJ MGP_FVBNJ_G0024880
 protein coding gene Chr19:33889232-34076713 (-)
LP/J MGP_LPJ_G0025005
 protein coding gene Chr19:36054623-36250533 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024911
 protein coding gene Chr19:38557070-38760566 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025550
 protein coding gene Chr19:35474225-35668057 (-)
PWK/PhJ MGP_PWKPhJ_G0024029
 protein coding gene Chr19:33912220-34106461 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023829
 protein coding gene Chr19:34297168-34498620 (-)
WSB/EiJ MGP_WSBEiJ_G0024344
 protein coding gene Chr19:35562555-35757994 (-)



Homology
more
  • Human Ortholog
    CPEB3, cytoplasmic polyadenylation element binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPEB3, cytoplasmic polyadenylation element binding protein 3
  • Links
    NCBI Gene ID: 22849
    neXtProt AC: NX_Q8NE35
    UniProt: Q8NE35

  • Chr Location
    10q23.32; chr10:92046692-92291233 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show female subfertility with impaired ovarian folliculogenesis and premature ovarian failure. Homozygotes for a null allele show increased anxiety, enhanced contextual conditioning behavior and consolidated spatial memory, hypolocomotion, and abnormal hippocampus pyramidal cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    9
  • cDNA Data
    11
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039652 Ensembl Gene Model | MGI Sequence Detail 187310 C57BL/6J ±  kb
    transcript ENSMUST00000079754 Ensembl | MGI Sequence Detail 5899 Not Applicable  
    polypeptide ENSMUSP00000078690 Ensembl | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000005807 cytoplasmic polyadenylation element-binding protein 3
      (term hierarchy)
    • InterPro Domains
      IPR038446 CEBP, ZZ domain superfamily
      IPR034819 Cytoplasmic polyadenylation element-binding protein
      IPR032296 Cytoplasmic polyadenylation element-binding protein, ZZ domain
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    • GlyGen
      Q7TN99 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 3

      Microarray probesets 7
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Gene Ontology 15
      Phenotypes 20
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:349160 Lamacova L, et al., CPEB3 Maintains Developmental Competence of the Oocyte. Cells. 2024 May 16;13(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory