Cntln MGI Mouse Gene Detail - MGI:2443104 - centlein, centrosomal protein

Symbol

Cntln
Name

centlein, centrosomal protein
Synonyms

B430108F07Rik, D530005L17Rik

Feature Type

protein coding gene
IDs

MGI:2443104
NCBI Gene: 338349
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr4:84802546-85050158 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 40.20 cM
Mapping Data

2 experiments

SNPs within 2kb

6372 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443104	protein coding gene	Chr4:84800024-85050160 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028407	protein coding gene	Chr4:84529537-84811064 (+)
A/J	MGP_AJ_G0028368	protein coding gene	Chr4:81610015-81857252 (+)
AKR/J	MGP_AKRJ_G0028317	protein coding gene	Chr4:83707973-83958091 (+)
BALB/cJ	MGP_BALBcJ_G0028388	protein coding gene	Chr4:81829858-82073172 (+)
C3H/HeJ	MGP_C3HHeJ_G0028103	protein coding gene	Chr4:84335132-84590486 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028827	protein coding gene	Chr4:87834167-88109719 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026127	protein coding gene	Chr4:77542277-77778518 (+)
CAST/EiJ	MGP_CASTEiJ_G0027544	protein coding gene	Chr4:82238680-82502320 (+)
CBA/J	MGP_CBAJ_G0028072	protein coding gene	Chr4:90522436-90795628 (+)
DBA/2J	MGP_DBA2J_G0028221	protein coding gene	Chr4:81386256-81648788 (+)
FVB/NJ	MGP_FVBNJ_G0028187	protein coding gene	Chr4:80381375-80629962 (+)
LP/J	MGP_LPJ_G0028321	protein coding gene	Chr4:84890494-85156209 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028216	protein coding gene	Chr4:95628061-95906486 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028864	protein coding gene	Chr4:83771435-84030588 (+)
PWK/PhJ	MGP_PWKPhJ_G0027267	protein coding gene	Chr4:79736403-79989154 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027092	protein coding gene	Chr4:81336539-81606556 (+)
WSB/EiJ	MGP_WSBEiJ_G0027620	protein coding gene	Chr4:83941717-84204592 (+)

Human Ortholog

CNTLN, centlein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNTLN, centlein
Synonyms

bA340N12.1, C9orf101, C9orf39
Links

HGNC:23432

NCBI Gene ID: 54875

neXtProt AC: NX_Q9NXG0

UniProt: Q9NXG0
Chr Location

9p22.2; chr9:17134982-17528634 (+) GRCh38

MGI Vertebrate Homology

Cntln stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CNTLN
Gene Tree

Cntln

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Cntln
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

75 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null allele exhibit infertility due to impaired head to tail anchorage of spermatids.

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All GO Annotations

31
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cntln

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All Sequences

74
RefSeq

23
UniProt

1
CCDS

CCDS18302.1, CCDS51216.1

Ensembl

ENSMUSG00000038070 (Evidence)
NCBI Gene

338349

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038070	Ensembl Gene Model \| MGI Sequence Detail	247613	C57BL/6J	± kb
transcript	ENSMUST00000047023	Ensembl \| MGI Sequence Detail	5528	Not Applicable
polypeptide	ENSMUSP00000044138	Ensembl \| MGI Sequence Detail	1397	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005665 centlein

(term hierarchy)
InterPro Domains

IPR038810 Centlein

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All nucleic 22

cDNA 22

Microarray probesets 3

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MGI:1925769, MGI:2140280

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:341535 Li L, et al., A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation. Acta Biochim Biophys Sin (Shanghai). 2023 Jul 20;55(9):1434-1444

TSS for Cntln:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37702	Chr4:84802513-84802551 (+)	-14 bp
Tssr37703	Chr4:84802603-84802644 (+)	78 bp
Tssr37704	Chr4:84802655-84802694 (+)	129 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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