Larp4 MGI Mouse Gene Detail - MGI:2443114

Symbol

Larp4
Name

La ribonucleoprotein 4
Synonyms

D330037H05Rik

Feature Type

protein coding gene
IDs

MGI:2443114
NCBI Gene: 207214
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:99867946-99914239 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.13 cM
Mapping Data

2 experiments

SNPs within 2kb

787 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443114	protein coding gene	Chr15:99867946-99914239 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022346	protein coding gene	Chr15:101870924-101918318 (+)
A/J	MGP_AJ_G0022304	protein coding gene	Chr15:97813224-97855830 (+)
AKR/J	MGP_AKRJ_G0022280	protein coding gene	Chr15:100813617-100856334 (+)
BALB/cJ	MGP_BALBcJ_G0022310	protein coding gene	Chr15:97975562-98022367 (+)
C3H/HeJ	MGP_C3HHeJ_G0022078	protein coding gene	Chr15:100880963-100931092 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022755	protein coding gene	Chr15:105662900-105718008 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020281	protein coding gene	Chr15:93672142-93715831 (+)
CAST/EiJ	MGP_CASTEiJ_G0021602	protein coding gene	Chr15:101740771-101801090 (+)
CBA/J	MGP_CBAJ_G0022047	protein coding gene	Chr15:109273562-109330719 (+)
DBA/2J	MGP_DBA2J_G0022174	protein coding gene	Chr15:97231584-97278050 (+)
FVB/NJ	MGP_FVBNJ_G0022154	protein coding gene	Chr15:96227314-96276163 (+)
LP/J	MGP_LPJ_G0022245	protein coding gene	Chr15:102008387-102061690 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022174	protein coding gene	Chr15:113141149-113192744 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022770	protein coding gene	Chr15:100928262-100978342 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0021176	protein coding gene	Chr15:100771906-100818406 (+)
WSB/EiJ	MGP_WSBEiJ_G0021653	protein coding gene	Chr15:101455224-101498609 (+)

Human Ortholog

LARP4, La ribonucleoprotein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LARP4, La ribonucleoprotein 4
Synonyms

PP13296
Links

HGNC:24320

NCBI Gene ID: 113251

neXtProt AC: NX_Q71RC2

UniProt: Q71RC2
Chr Location

12q13.12; chr12:50392383-50480004 (+) GRCh38

MGI Vertebrate Homology

Larp4 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: LARP4
Gene Tree

Larp4

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

28
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Larp4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available

MEFs from homozygous mice show reduced ribosomal protein poly A tail length and reduced ribosomal protein stability.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase larp4

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All Sequences

84
RefSeq

14
UniProt

8
CCDS

CCDS37208.1, CCDS49730.1, CCDS88842.1

Ensembl

ENSMUSG00000023025 (Evidence)
NCBI Gene

207214

			Length	Strain/Species	Flank
genomic	207214	NCBI Gene Model \| MGI Sequence Detail	46294	C57BL/6J	± kb
transcript	NM_001080948	RefSeq \| MGI Sequence Detail	6553	C57BL/6
polypeptide	Q8BWW4	UniProt \| EBI \| MGI Sequence Detail	719	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000009670 La-related protein 4

(term hierarchy)
InterPro Domains

IPR045180 La domain containing protein

IPR034903 LARP4, RNA recognition motif

IPR006630 La-type HTH domain

IPR035979 RNA-binding domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q8BWW4 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 7

Summaries

All 55

Diseases 1

Gene Ontology 5

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:295976 Tian Y, et al., Transcriptome-wide stability analysis uncovers LARP4-mediated NFkappaB1 mRNA stabilization during T cell activation. Nucleic Acids Res. 2020 Sep 4;48(15):8724-8739

TSS for Larp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133076	Chr15:99870691-99870702 (+)	2,751 bp
Tssr133077	Chr15:99870715-99870777 (+)	2,800 bp
Tssr133078	Chr15:99870787-99870806 (+)	2,851 bp
Tssr133079	Chr15:99903026-99903041 (+)	35,088 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24