Ptgs2os MGI Mouse Gene Detail - MGI:2443180 - prostaglandin-endoperoxide synthase 2, opposite strand

Symbol

Ptgs2os
Name

prostaglandin-endoperoxide synthase 2, opposite strand
Synonyms

7530420F21Rik

Feature Type

lncRNA gene
IDs

MGI:2443180
NCBI Gene: 320019
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:149950624-149975625 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 63.84 cM
Mapping Data

1 experiment

SNPs within 2kb

904 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443180	lncRNA gene	Chr1:149950624-149975714 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015118	unclassified non-coding RNA gene	Chr1:154710424-154740502 (-)
A/J	MGP_AJ_G0015091	unclassified non-coding RNA gene	Chr1:148450582-148484143 (-)
AKR/J	MGP_AKRJ_G0015054	unclassified non-coding RNA gene	Chr1:152981181-153014295 (-)
BALB/cJ	MGP_BALBcJ_G0015054	unclassified non-coding RNA gene	Chr1:149013424-149038666 (-)
C3H/HeJ	MGP_C3HHeJ_G0014877	unclassified non-coding RNA gene	Chr1:153186907-153215807 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0015511	unclassified non-coding RNA gene	Chr1:160048064-160079411 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013257	unclassified non-coding RNA gene	Chr1:140787085-140811804 (-)
CAST/EiJ	MGP_CASTEiJ_G0014432	unclassified non-coding RNA gene	Chr1:152617417-152643447 (-)
CBA/J	MGP_CBAJ_G0014856	unclassified non-coding RNA gene	Chr1:165730091-165765027 (-)
DBA/2J	MGP_DBA2J_G0014949	unclassified non-coding RNA gene	Chr1:147520398-147545584 (-)
FVB/NJ	MGP_FVBNJ_G0014961	unclassified non-coding RNA gene	Chr1:145960260-145985720 (-)
LP/J	MGP_LPJ_G0015032	unclassified non-coding RNA gene	Chr1:155712525-155742485 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0014987	unclassified non-coding RNA gene	Chr1:173408030-173453400 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0015549	unclassified non-coding RNA gene	Chr1:152810430-152837972 (-)
PWK/PhJ	MGP_PWKPhJ_G0014224	unclassified non-coding RNA gene	Chr1:146448466-146477419 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014012	unclassified non-coding RNA gene	Chr1:151461318-151538684 (-)
WSB/EiJ	MGP_WSBEiJ_G0014535	unclassified non-coding RNA gene	Chr1:152909729-152938776 (-)

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Gene Tree

Ptgs2os

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

2 involving Ptgs2os
Find Mice (IMSR)

0 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased susceptibility to LPS-induced lung inflammation.

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All GO Annotations

10
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

27
RefSeq

1

Ensembl

ENSMUSG00000097028 (Evidence)
NCBI Gene

320019

Representative Sequences				Length	Strain/Species	Flank
	genomic	320019	NCBI Gene Model \| MGI Sequence Detail	25002	C57BL/6J	± kb
	transcript	NR_015466	RefSeq \| MGI Sequence Detail	2994	C57BL/6

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All nucleic 6

cDNA 6

Summaries

All 12

Gene Ontology 1

Phenotypes 3
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:325487 Robinson EK, et al., lincRNA-Cox2 Functions to Regulate Inflammation in Alveolar Macrophages during Acute Lung Injury. J Immunol. 2022 Apr 15;208(8):1886-1900

TSS for Ptgs2os:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14131	Chr1:149977016-149977069 (-)	-1,418 bp
Tssr14130	Chr1:149976993-149977013 (-)	-1,378 bp
Tssr14129	Chr1:149975419-149975436 (-)	197 bp
Tssr14128	Chr1:149975322-149975361 (-)	283 bp
Tssr14127	Chr1:149975291-149975306 (-)	326 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24