Fstl4 MGI Mouse Gene Detail - MGI:2443199

Symbol

Fstl4
Name

follistatin-like 4
Synonyms

B230374F23Rik, SPIG1

Feature Type

protein coding gene
IDs

MGI:2443199
NCBI Gene: 320027
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:52655461-53079365 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 31.86 cM
Mapping Data

1 experiment

SNPs within 2kb

12072 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443199	protein coding gene	Chr11:52655320-53083277 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018286	protein coding gene	Chr11:52114296-52549601 (+)
A/J	MGP_AJ_G0018255	protein coding gene	Chr11:50165410-50586783 (+)
AKR/J	MGP_AKRJ_G0018225	protein coding gene	Chr11:51792378-52229023 (+)
BALB/cJ	MGP_BALBcJ_G0018226	protein coding gene	Chr11:50506016-50937975 (+)
C3H/HeJ	MGP_C3HHeJ_G0018037	protein coding gene	Chr11:51757015-52194049 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018678	protein coding gene	Chr11:53689711-54130062 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016328	protein coding gene	Chr11:47646193-48112926 (+)
CAST/EiJ	MGP_CASTEiJ_G0017602	protein coding gene	Chr11:51796765-52236328 (+)
CBA/J	MGP_CBAJ_G0018012	protein coding gene	Chr11:56220242-56675249 (+)
DBA/2J	MGP_DBA2J_G0018122	protein coding gene	Chr11:49906623-50332020 (+)
FVB/NJ	MGP_FVBNJ_G0018114	protein coding gene	Chr11:49548022-49970523 (+)
LP/J	MGP_LPJ_G0018196	protein coding gene	Chr11:52550359-52992818 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018138	protein coding gene	Chr11:57554428-58008942 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018720	protein coding gene	Chr11:51832184-52261982 (+)
PWK/PhJ	MGP_PWKPhJ_G0017377	protein coding gene	Chr11:50402514-50838928 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017172	protein coding gene	Chr11:51632854-52075782 (+)
WSB/EiJ	MGP_WSBEiJ_G0017649	protein coding gene	Chr11:51448143-51889414 (+)

Human Ortholog

FSTL4, follistatin like 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FSTL4, follistatin like 4
Links

HGNC:21389

NCBI Gene ID: 23105

neXtProt AC: NX_Q6MZW2

UniProt: Q6MZW2
Chr Location

5q31.1; chr5:133196455-133842067 (-) GRCh38

MGI Vertebrate Homology

Fstl4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FSTL4
Gene Tree

Fstl4

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Fstl4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice were born at expected Mendelian ratio and healthy, fertile, apparently normal with normal retinal laminar structure.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

6
cDNA Data

5
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN fstl4

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All Sequences

40
RefSeq

5
UniProt

2
CCDS

CCDS24673.1

Ensembl

ENSMUSG00000036264 (Evidence)
NCBI Gene

320027

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036264	Ensembl Gene Model \| MGI Sequence Detail	423905	C57BL/6J	± kb
transcript	ENSMUST00000036796	Ensembl \| MGI Sequence Detail	4380	Not Applicable
polypeptide	ENSMUSP00000042007	Ensembl \| MGI Sequence Detail	841	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007687 follistatin-related protein 4

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR002350 Kazal domain

IPR036058 Kazal domain superfamily

IPR050653 Protease Inhibitors and Growth Factor Antagonists

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q5STE3 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 6

cDNA 5

Other 1

Microarray probesets 2

Summaries

All 36

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:338268 Dos Santos M, et al., Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution. Nat Commun. 2023 Jul 19;14(1):4333

TSS for Fstl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101373	Chr11:52655478-52655520 (+)	38 bp
Tssr101374	Chr11:52707194-52707197 (+)	51,735 bp
Tssr101375	Chr11:52711041-52711043 (+)	55,581 bp
Tssr101376	Chr11:52751251-52751253 (+)	95,791 bp
Tssr101377	Chr11:53078433-53078438 (+)	422,975 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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