Zfp384 MGI Mouse Gene Detail - MGI:2443203

Symbol

Zfp384
Name

zinc finger protein 384
Synonyms

C130073D16Rik, Ciz, Nmp4

Feature Type

protein coding gene
IDs

MGI:2443203
NCBI Gene: 269800
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:124986108-125014833 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.17 cM, cytoband F1
Mapping Data

4 experiments

SNPs within 2kb

587 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443203	protein coding gene	Chr6:124985980-125014833 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031281	protein coding gene	Chr6:128324682-128362072 (+)
A/J	MGP_AJ_G0031251	protein coding gene	Chr6:123490573-123519989 (+)
AKR/J	MGP_AKRJ_G0031179	protein coding gene	Chr6:126862724-126895775 (+)
BALB/cJ	MGP_BALBcJ_G0031259	protein coding gene	Chr6:123088451-123117331 (+)
C3H/HeJ	MGP_C3HHeJ_G0030982	protein coding gene	Chr6:126920630-126950584 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031715	protein coding gene	Chr6:131709511-131741637 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028865	protein coding gene	Chr6:120695652-120725901 (+)
CAST/EiJ	MGP_CASTEiJ_G0030363	protein coding gene	Chr6:127127181-127155868 (+)
CBA/J	MGP_CBAJ_G0030943	protein coding gene	Chr6:136746560-136781378 (+)
DBA/2J	MGP_DBA2J_G0031099	protein coding gene	Chr6:122418337-122452008 (+)
FVB/NJ	MGP_FVBNJ_G0031049	protein coding gene	Chr6:121321664-121358188 (+)
LP/J	MGP_LPJ_G0031179	protein coding gene	Chr6:128495150-128525071 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031087	protein coding gene	Chr6:140795866-140829613 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031750	protein coding gene	Chr6:126757083-126787423 (+)
PWK/PhJ	MGP_PWKPhJ_G0030078	protein coding gene	Chr6:120655736-120683010 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029907	protein coding gene	Chr6:124838233-124868446 (+)
WSB/EiJ	MGP_WSBEiJ_G0030448	protein coding gene	Chr6:127123062-127153338 (+)

Human Ortholog

ZNF384, zinc finger protein 384

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF384, zinc finger protein 384
Synonyms

CAGH1, CAGH1A, CIZ, ERDA2, NMP4, NP, TNRC1
Links

HGNC:11955

NCBI Gene ID: 171017

neXtProt AC: NX_Q8TF68

UniProt: Q8TF68
Chr Location

chr12:6666477-6689572 (-) GRCh38

MGI Vertebrate Homology

Zfp384 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZNF384
Gene Tree

Zfp384

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

1
Gene trapped

12
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice are small and males have a small testis. Some males develop infertility and exhibit variable degrees of spermatogenic cell degeneration within the seminiferous tubules and increased apoptosis of spermatogenic cells.

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All GO Annotations

13
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

15
cDNA Data

38
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase znf384

ZFIN znf384a, znf384b

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All Sequences

135
RefSeq

58
UniProt

13
CCDS

CCDS39631.1, CCDS57448.1, CCDS90119.1

Ensembl

ENSMUSG00000038346 (Evidence)
NCBI Gene

269800

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038346	Ensembl Gene Model \| MGI Sequence Detail	28726	C57BL/6J	± kb
transcript	ENSMUST00000112427	Ensembl \| MGI Sequence Detail	3072	Not Applicable
polypeptide	ENSMUSP00000108046	Ensembl \| MGI Sequence Detail	584	Not Applicable

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UniProt

13 Sequences
InterPro Domains

IPR050331 Zinc finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

E9Q1A5 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 41

Genomic 1

cDNA 38

Primer pair 2

Microarray probesets 2

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MGI:1927291, MGI:2141735

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 19
Earliest

J:75532 Alvarez MB, et al., Assignment of Nmp4 to mouse chromosome 6 band F1 flanked by D6Mit134 and D6Mit255 using radiation hybrid mapping and fluorescence in situ hybridization. Cytogenet Cell Genet. 2001;94(3-4):244-5
Latest

J:334030 Atkinson EG, et al., Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation. J Bone Miner Res. 2023 Jan;38(1):70-85

TSS for Zfp384:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58886	Chr6:124985961-124986006 (+)	-124 bp
Tssr58887	Chr6:124986076-124986105 (+)	-17 bp
Tssr58888	Chr6:124986195-124986216 (+)	98 bp
Tssr58889	Chr6:124986224-124986280 (+)	144 bp
Tssr58890	Chr6:124986628-124986680 (+)	546 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24