Siglech MGI Mouse Gene Detail - MGI:2443256 - sialic acid binding Ig-like lectin H

Symbol

Siglech
Name

sialic acid binding Ig-like lectin H
Synonyms

6430529G09Rik, Siglec-H

Feature Type

protein coding gene
IDs

MGI:2443256
NCBI Gene: 233274
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:55417926-55428673 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 33.42 cM
Mapping Data

2 experiments

SNPs within 2kb

474 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443256	protein coding gene	Chr7:55417916-55429196 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032311	protein coding gene	Chr7:56572825-56584495 (+)
A/J	MGP_AJ_G0032290	protein coding gene	Chr7:55713252-55723980 (+)
AKR/J	MGP_AKRJ_G0032226	protein coding gene	Chr7:57021960-57033172 (+)
BALB/cJ	MGP_BALBcJ_G0032302	protein coding gene	Chr7:55333014-55343740 (+)
C3H/HeJ	MGP_C3HHeJ_G0032015	protein coding gene	Chr7:57368888-57380536 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032795	protein coding gene	Chr7:59138176-59148949 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029802	protein coding gene	Chr7:58387733-58399062 (+)
CAST/EiJ	MGP_CASTEiJ_G0031344	protein coding gene	Chr7:48576873-48587810 (+)
CBA/J	MGP_CBAJ_G0031980	protein coding gene	Chr7:61169272-61179988 (+)
DBA/2J	MGP_DBA2J_G0032137	protein coding gene	Chr7:54738209-54749299 (+)
FVB/NJ	MGP_FVBNJ_G0032091	protein coding gene	Chr7:54696150-54707314 (+)
LP/J	MGP_LPJ_G0032218	protein coding gene	Chr7:57629807-57642436 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032128	protein coding gene	Chr7:60707584-60719382 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032812	protein coding gene	Chr7:56000786-56013224 (+)
PWK/PhJ	MGP_PWKPhJ_G0031064	protein coding gene	Chr7:48002011-48013304 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030905	protein coding gene	Chr7:44056685-44068603 (+)
WSB/EiJ	MGP_WSBEiJ_G0031462	protein coding gene	Chr7:56650994-56662622 (+)

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MGI Vertebrate Homology

Siglech stringent orthology
1 mouse;1 rat;3 zebrafish
Gene Tree

Siglech

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
13 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

7
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit increased T cell proliferation, increased BUN, vacuolated renal tubules, testicular atrophy and poor maturation of seminiferous tubules.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

6
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

91
RefSeq

32
UniProt

9
CCDS

CCDS21313.2, CCDS80731.1, CCDS80732.1

Ensembl

ENSMUSG00000051504 (Evidence)
NCBI Gene

233274

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051504	Ensembl Gene Model \| MGI Sequence Detail	10748	C57BL/6J	± kb
transcript	ENSMUST00000165045	Ensembl \| MGI Sequence Detail	1062	Not Applicable
polypeptide	ENSMUSP00000130632	Ensembl \| MGI Sequence Detail	332	Not Applicable

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UniProt

9 Sequences
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR051036 Sialic acid-binding Ig-like lectin
GlyGen

B7ZMQ6 6 sites, 5 N-linked glycans (6 sites)

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 23
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:337732 Valente M, et al., Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells. Nat Immunol. 2023 Apr;24(4):714-728

TSS for Siglech:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66915	Chr7:55417921-55417935 (+)	2 bp
Tssr66916	Chr7:55417966-55417981 (+)	48 bp
Tssr66917	Chr7:55418003-55418014 (+)	83 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24