Itgbl1 MGI Mouse Gene Detail - MGI:2443439

Symbol

Itgbl1
Name

integrin, beta-like 1
Synonyms

B930011D01Rik, with EGF-like repeat domains

Feature Type

protein coding gene
IDs

MGI:2443439
NCBI Gene: 223272
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:123897383-124213030 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 66.10 cM
Mapping Data

1 experiment

SNPs within 2kb

4924 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443439	protein coding gene	Chr14:123897331-124215173 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021678	protein coding gene	Chr14:121604101-121891564 (+)
A/J	MGP_AJ_G0021638	protein coding gene	Chr14:116901571-117188670 (+)
AKR/J	MGP_AKRJ_G0021614	protein coding gene	Chr14:120668788-120993079 (+)
BALB/cJ	MGP_BALBcJ_G0021644	protein coding gene	Chr14:117452635-117762695 (+)
C3H/HeJ	MGP_C3HHeJ_G0021421	protein coding gene	Chr14:120563673-120875365 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022084	protein coding gene	Chr14:126263365-126567189 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019622	protein coding gene	Chr14:112661184-112901242 (+)
CAST/EiJ	MGP_CASTEiJ_G0020937	protein coding gene	Chr14:118453774-118735673 (+)
CBA/J	MGP_CBAJ_G0021390	protein coding gene	Chr14:131082871-131396488 (+)
DBA/2J	MGP_DBA2J_G0021513	protein coding gene	Chr14:116776914-117043312 (+)
FVB/NJ	MGP_FVBNJ_G0021491	protein coding gene	Chr14:115083607-115390415 (+)
LP/J	MGP_LPJ_G0021581	protein coding gene	Chr14:122518175-122816605 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021518	protein coding gene	Chr14:136069755-136444331 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022107	protein coding gene	Chr14:120229232-120509019 (+)
PWK/PhJ	MGP_PWKPhJ_G0020681	protein coding gene	Chr14:113793885-114050357 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020519	protein coding gene	Chr14:116430709-116683757 (+)
WSB/EiJ	MGP_WSBEiJ_G0020993	protein coding gene	Chr14:120899850-121171365 (+)

Human Ortholog

ITGBL1, integrin subunit beta like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITGBL1, integrin subunit beta like 1
Synonyms

OSCP, TIED
Links

HGNC:6164

NCBI Gene ID: 9358

neXtProt AC: NX_O95965

UniProt: O95965
Chr Location

13q33.1; chr13:101452593-101720856 (+) GRCh38

MGI Vertebrate Homology

Itgbl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ITGBL1
Gene Tree

Itgbl1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

6
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

776
Tissues

14
cDNA Data

14
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase itgbl1

ZFIN itgbl1

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All Sequences

43
RefSeq

4
UniProt

3
CCDS

CCDS27354.1

Ensembl

ENSMUSG00000032925 (Evidence)
NCBI Gene

223272

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032925	Ensembl Gene Model \| MGI Sequence Detail	315648	C57BL/6J	± kb
transcript	ENSMUST00000049681	Ensembl \| MGI Sequence Detail	4065	Not Applicable
polypeptide	ENSMUSP00000059019	Ensembl \| MGI Sequence Detail	494	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009145 integrin beta-like protein 1

(term hierarchy)
InterPro Domains

IPR000742 EGF-like domain

IPR013111 EGF-like domain, extracellular

IPR015812 Integrin beta subunit
GlyGen

Q8VDV0 1 site

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All nucleic 14

cDNA 14

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:322406 Song EK, et al., ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis. Sci Transl Med. 2018 Oct 10;10(462)

TSS for Itgbl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127373	Chr14:123897527-123897621 (+)	191 bp
Tssr127374	Chr14:123897633-123897645 (+)	256 bp
Tssr127375	Chr14:123897677-123897696 (+)	304 bp
Tssr127376	Chr14:123897703-123897723 (+)	330 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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