Mrm1 MGI Mouse Gene Detail - MGI:2443470 - mitochondrial rRNA methyltransferase 1

Symbol

Mrm1
Name

mitochondrial rRNA methyltransferase 1
Synonyms

A530065E19Rik

Feature Type

protein coding gene
IDs

MGI:2443470
NCBI Gene: 217038
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:84703887-84710341 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.34 cM
Mapping Data

2 experiments

SNPs within 2kb

298 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443470	protein coding gene	Chr11:84703887-84710341 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018871	protein coding gene	Chr11:86262269-86268689 (-)
A/J	MGP_AJ_G0018838	protein coding gene	Chr11:82971577-82977996 (-)
AKR/J	MGP_AKRJ_G0018808	protein coding gene	Chr11:85425950-85434375 (-)
BALB/cJ	MGP_BALBcJ_G0018811	protein coding gene	Chr11:83360431-83367311 (-)
C3H/HeJ	MGP_C3HHeJ_G0018625	protein coding gene	Chr11:85483911-85490322 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019263	protein coding gene	Chr11:88885938-88892354 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016896	protein coding gene	Chr11:80059173-80066013 (-)
CAST/EiJ	MGP_CASTEiJ_G0018180	protein coding gene	Chr11:86119675-86126132 (-)
CBA/J	MGP_CBAJ_G0018596	protein coding gene	Chr11:92648199-92659270 (-)
DBA/2J	MGP_DBA2J_G0018704	protein coding gene	Chr11:82543624-82551040 (-)
FVB/NJ	MGP_FVBNJ_G0018693	protein coding gene	Chr11:82038222-82044636 (-)
LP/J	MGP_LPJ_G0018774	protein coding gene	Chr11:86789120-86795559 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018720	protein coding gene	Chr11:92798422-92806683 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019303	protein coding gene	Chr11:85704383-85710841 (-)
PWK/PhJ	MGP_PWKPhJ_G0017949	protein coding gene	Chr11:83317380-83324446 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017741	protein coding gene	Chr11:85251614-85261756 (-)
WSB/EiJ	MGP_WSBEiJ_G0018231	protein coding gene	Chr11:85547789-85554243 (-)

Human Ortholog

MRM1, mitochondrial rRNA methyltransferase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRM1, mitochondrial rRNA methyltransferase 1
Links

HGNC:26202

NCBI Gene ID: 79922

neXtProt AC: NX_Q6IN84

UniProt: Q6IN84
Chr Location

17q12; chr17:36601583-36634698 (+) GRCh38

MGI Vertebrate Homology

Mrm1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRM1
Gene Tree

Mrm1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

6
Genomic Mutations

3 involving Mrm1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

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All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

30
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

2
UniProt

1
CCDS

CCDS36260.1

Ensembl

ENSMUSG00000018405 (Evidence)
NCBI Gene

217038

			Length	Strain/Species	Flank
genomic	217038	NCBI Gene Model \| MGI Sequence Detail	6455	C57BL/6J	± kb
transcript	NM_145433	RefSeq \| MGI Sequence Detail	2490	Not Specified
polypeptide	Q99J25	UniProt \| EBI \| MGI Sequence Detail	320	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010568 rRNA methyltransferase 1, mitochondrial

(term hierarchy)
EC

2.1.1.-
InterPro Domains

IPR029028 Alpha/beta knot methyltransferases

IPR029064 Ribosomal protein eL30-like superfamily

IPR013123 RNA 2-O ribose methyltransferase, substrate binding

IPR047261 rRNA methyltransferase 1, methyltransferase domain

IPR047182 rRNA methyltransferase 1, mitochondrial

IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal

IPR001537 tRNA/rRNA methyltransferase, SpoU type

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All nucleic 33

Genomic 1

cDNA 32

Microarray probesets 4

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mrm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109769	Chr11:84710276-84710297 (-)	54 bp
Tssr109768	Chr11:84710216-84710241 (-)	112 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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