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Ccdc28a Gene Detail
Summary
  • Symbol
    Ccdc28a
  • Name
    coiled-coil domain containing 28A
  • Synonyms
    1700009P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443508
    NCBI Gene: 215814
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:18089424-18110746 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 7.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    743 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443508
 protein coding gene Chr10:18089424-18110940 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017037
 protein coding gene Chr10:15883209-15906665 (-)
A/J MGP_AJ_G0017015
 protein coding gene Chr10:15282399-15302286 (-)
AKR/J MGP_AKRJ_G0016979
 protein coding gene Chr10:15519597-15541506 (-)
BALB/cJ MGP_BALBcJ_G0016973
 protein coding gene Chr10:15347323-15366251 (-)
C3H/HeJ MGP_C3HHeJ_G0016798
 protein coding gene Chr10:15863167-15884241 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017435
 protein coding gene Chr10:16272502-16292847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015140
 protein coding gene Chr10:14175694-14194142 (-)
CAST/EiJ MGP_CASTEiJ_G0016380
 protein coding gene Chr10:15655738-15676703 (-)
CBA/J MGP_CBAJ_G0016770
 protein coding gene Chr10:17002240-17024255 (-)
DBA/2J MGP_DBA2J_G0016878
 protein coding gene Chr10:15172755-15192543 (-)
FVB/NJ MGP_FVBNJ_G0016873
 protein coding gene Chr10:14934588-14955281 (-)
LP/J MGP_LPJ_G0016953
 protein coding gene Chr10:15709458-15729313 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016903
 protein coding gene Chr10:17350856-17374763 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017473
 protein coding gene Chr10:15490257-15513357 (-)
PWK/PhJ MGP_PWKPhJ_G0016165
 protein coding gene Chr10:14990961-15009960 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015948
 protein coding gene Chr10:15652643-15672201 (-)
WSB/EiJ MGP_WSBEiJ_G0016442
 protein coding gene Chr10:15577972-15598487 (-)



Homology
more
  • Human Ortholog
    CCDC28A, coiled-coil domain containing 28A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC28A, coiled-coil domain containing 28A
  • Synonyms
    C6orf80, CCRL1AP
  • Links
    NCBI Gene ID: 25901
    neXtProt AC: NX_Q8IWP9
    UniProt: Q8IWP9

  • Chr Location
    6q24.1; chr6:138773769-138793319 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males are infertile, with decreased sperm motility and sperm head defects that include bent heads, small heads, and irregular shapes and abnormal acrosome structures.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    39
  • cDNA Data
    77
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059554 Ensembl Gene Model | MGI Sequence Detail 21323 C57BL/6J ±  kb
    transcript ENSMUST00000052648 Ensembl | MGI Sequence Detail 2255 Not Applicable  
    polypeptide ENSMUSP00000050107 Ensembl | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR025271 Coiled-coil domain-containing protein 28
    • GlyGen
      Q8CEI3 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 77

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2143626
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350809 Zhou H, et al., CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice. Cell Mol Life Sci. 2024 Apr 10;81(1):174
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory