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Tacc1 Gene Detail
Summary
  • Symbol
    Tacc1
  • Name
    transforming, acidic coiled-coil containing protein 1
  • Synonyms
    4833447E04Rik, B230378H13Rik, Tacc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443510
    NCBI Gene: 320165
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25644568-25730901 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 13.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2541 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443510
 protein coding gene Chr8:25644568-25746604 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033480
 protein coding gene Chr8:23165686-23212428 (-)
A/J MGP_AJ_G0033460
 protein coding gene Chr8:22347484-22394679 (-)
AKR/J MGP_AKRJ_G0033385
 protein coding gene Chr8:23082192-23129328 (-)
BALB/cJ MGP_BALBcJ_G0033456
 protein coding gene Chr8:22493843-22540666 (-)
C3H/HeJ MGP_C3HHeJ_G0033170
 protein coding gene Chr8:23290233-23338879 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033972
 protein coding gene Chr8:24117720-24164611 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030922
 protein coding gene Chr8:19625690-19674180 (-)
CAST/EiJ MGP_CASTEiJ_G0032496
 protein coding gene Chr8:22712135-22761958 (-)
CBA/J MGP_CBAJ_G0033145
 protein coding gene Chr8:25052143-25107498 (-)
DBA/2J MGP_DBA2J_G0033300
 protein coding gene Chr8:22322610-22369426 (-)
FVB/NJ MGP_FVBNJ_G0033244
 protein coding gene Chr8:22121001-22170858 (-)
LP/J MGP_LPJ_G0033389
 protein coding gene Chr8:23148079-23196507 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033287
 protein coding gene Chr8:24542445-24591789 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033991
 protein coding gene Chr8:23021219-23069867 (-)
PWK/PhJ MGP_PWKPhJ_G0032207
 protein coding gene Chr8:21932682-21981055 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032041
 protein coding gene Chr8:22363043-22414659 (-)
WSB/EiJ MGP_WSBEiJ_G0032612
 protein coding gene Chr8:23222920-23271426 (-)



Homology
more
  • Human Ortholog
    TACC1, transforming acidic coiled-coil containing protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TACC1, transforming acidic coiled-coil containing protein 1
  • Synonyms
    Ga55
  • Links
    NCBI Gene ID: 6867
    neXtProt AC: NX_O75410
    UniProt: O75410

  • Chr Location
    8p11.22; chr8:38728186-38853028 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    79
  • cDNA Data
    106
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 320165 NCBI Gene Model | MGI Sequence Detail 86334 C57BL/6J ±  kb
transcript NM_001402841 RefSeq | MGI Sequence Detail 7834 C57BL/6  
polypeptide Q6Y685 UniProt | EBI | MGI Sequence Detail 774 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000016006 transforming acidic coiled-coil-containing protein 1
    (term hierarchy)
  • InterPro Domains
    IPR039915 TACC family
    IPR007707 Transforming acidic coiled-coil-containing protein, C-terminal
  • GlyGen
    Q6Y685 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 107
    cDNA 106
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1926041, MGI:2142453
References
more
  • Summaries
    All 41
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory