About   Help   FAQ
Fermt1 Gene Detail
Summary
  • Symbol
    Fermt1
  • Name
    fermitin family member 1
  • Synonyms
    5830467P10Rik, Kindlin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443583
    NCBI Gene: 241639
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132746309-132787826 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1362 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443583
 protein coding gene Chr2:132746097-132787956 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026550
 protein coding gene Chr2:136536819-136584979 (-)
A/J MGP_AJ_G0026514
 protein coding gene Chr2:130959039-131001466 (-)
AKR/J MGP_AKRJ_G0026488
 protein coding gene Chr2:134746688-134790866 (-)
BALB/cJ MGP_BALBcJ_G0026526
 protein coding gene Chr2:131366999-131407580 (-)
C3H/HeJ MGP_C3HHeJ_G0026269
 protein coding gene Chr2:135183797-135229313 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026971
 protein coding gene Chr2:140684545-140729193 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024348
 protein coding gene Chr2:125683720-125730394 (-)
CAST/EiJ MGP_CASTEiJ_G0025730
 protein coding gene Chr2:135520506-135569151 (-)
CBA/J MGP_CBAJ_G0026249
 protein coding gene Chr2:145953921-146000738 (-)
DBA/2J MGP_DBA2J_G0026383
 protein coding gene Chr2:130346366-130387460 (-)
FVB/NJ MGP_FVBNJ_G0026347
 protein coding gene Chr2:128975424-129017119 (-)
LP/J MGP_LPJ_G0026487
 protein coding gene Chr2:136758238-136804848 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026367
 protein coding gene Chr2:149685181-149730000 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027026
 protein coding gene Chr2:134713581-134756551 (-)
PWK/PhJ MGP_PWKPhJ_G0025466
 protein coding gene Chr2:129960445-130005677 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025268
 protein coding gene Chr2:133875666-133923623 (-)
WSB/EiJ MGP_WSBEiJ_G0025804
 protein coding gene Chr2:135635328-135685705 (-)



Homology
more
  • Human Ortholog
    FERMT1, FERM domain containing kindlin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FERMT1, FERM domain containing kindlin 1
  • Synonyms
    C20orf42, DTGCU2, KIND1, UNC112A, URP1
  • Links
    NCBI Gene ID: 55612
    neXtProt AC: NX_Q9BQL6
    UniProt: Q9BQL6

  • Chr Location
    20p12.3; chr20:6074845-6123214 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fermt1 mouse models; 3 with human FERMT1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality within 5 days of birth, dehydration, detachment of colonic epithelial cells, and colonic inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    68
  • cDNA Data
    16
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027356 Ensembl Gene Model | MGI Sequence Detail 41518 C57BL/6J ±  kb
    transcript ENSMUST00000038280 Ensembl | MGI Sequence Detail 4915 Not Applicable  
    polypeptide ENSMUSP00000047616 Ensembl | MGI Sequence Detail 677 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 17
      Primer pair 3
      Other 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:288809 Zhang Z, et al., Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture. Circulation. 2019 Mar 19;139(12):1554-1556
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory