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Ddx11 Gene Detail
Summary
  • Symbol
    Ddx11
  • Name
    DEAD/H box helicase 11
  • Synonyms
    4732462I11Rik, CHL1, CHLR1, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11, essa15a, KRG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443590
    NCBI Gene: 320209
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66430515-66459169 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 35.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443590
 protein coding gene Chr17:66430508-66459169 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023986
 protein coding gene Chr17:68306768-68337967 (+)
A/J MGP_AJ_G0023944
 protein coding gene Chr17:66253147-66296538 (+)
AKR/J MGP_AKRJ_G0023913
 protein coding gene Chr17:67175943-67207746 (+)
BALB/cJ MGP_BALBcJ_G0023945
 protein coding gene Chr17:66201924-66232792 (+)
C3H/HeJ MGP_C3HHeJ_G0023709
 protein coding gene Chr17:68068976-68099718 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024391
 protein coding gene Chr17:70923941-70957336 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021837
 protein coding gene Chr17:62274028-62300554 (+)
CAST/EiJ MGP_CASTEiJ_G0023191
 protein coding gene Chr17:68420574-68455017 (+)
CBA/J MGP_CBAJ_G0023685
 protein coding gene Chr17:73714112-73749556 (+)
DBA/2J MGP_DBA2J_G0023813
 protein coding gene Chr17:64997078-65026196 (+)
FVB/NJ MGP_FVBNJ_G0023779
 protein coding gene Chr17:64485185-64514085 (+)
LP/J MGP_LPJ_G0023895
 protein coding gene Chr17:69012360-69047146 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023807
 protein coding gene Chr17:73802179-73833070 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024435
 protein coding gene Chr17:67633533-67665254 (+)
PWK/PhJ MGP_PWKPhJ_G0022937
 protein coding gene Chr17:64277642-64308398 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022748
 protein coding gene Chr17:64322992-64351559 (+)
WSB/EiJ MGP_WSBEiJ_G0023257
 protein coding gene Chr17:68337607-68370061 (+)



Homology
more
  • Human Ortholog
    DDX11, DEAD/H-box helicase 11
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX11, DEAD/H-box helicase 11
  • Synonyms
    CHL1, CHLR1, KRG2, WABS
  • Links
    NCBI Gene ID: 1663
    neXtProt AC: NX_Q96FC9
    UniProt: Q96FC9

  • Chr Location
    12p11.21; chr12:31073860-31104799 (+)  GRCh38
  • Human Ortholog
    DDX11L8, DEAD/H-box helicase 11 like 8 (pseudogene)
  • Links
    NCBI Gene ID: 100302090
    UniProt: A8MPP1

  • Chr Location
    chr12:12310-14526 (+)  GRCh38
  • Human Ortholog
    DDX12P, DEAD/H-box helicase 12, pseudogene
  • Synonyms
    CHLR2, DDX12
  • Links
    NCBI Gene ID: 440081
    UniProt: Q92771

  • Chr Location
    12p13.31; chr12:9417691-9448229 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DDX11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality before E11.5 with growth retardation, failure of chorioallantoic fusion, poor placental labyrinth development, and embryonic cell physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    7
  • cDNA Data
    30
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035842 Ensembl Gene Model | MGI Sequence Detail 28655 C57BL/6J ±  kb
    transcript ENSMUST00000224497 Ensembl | MGI Sequence Detail 4141 Not Applicable  
    polypeptide ENSMUSP00000153436 Ensembl | MGI Sequence Detail 906 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3578202
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory