Tmem203 MGI Mouse Gene Detail - MGI:2443597

Symbol

Tmem203
Name

transmembrane protein 203
Synonyms

C730025P13Rik

Feature Type

protein coding gene
IDs

MGI:2443597
NCBI Gene: 227615
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:25145451-25146304 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.11 cM
Mapping Data

1 experiment

SNPs within 2kb

102 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443597	protein coding gene	Chr2:25145451-25146364 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025432	protein coding gene	Chr2:23123237-23124090 (+)
A/J	MGP_AJ_G0025409	protein coding gene	Chr2:22234828-22235681 (+)
AKR/J	MGP_AKRJ_G0025379	protein coding gene	Chr2:22976727-22977580 (+)
BALB/cJ	MGP_BALBcJ_G0025405	protein coding gene	Chr2:22344678-22345531 (+)
C3H/HeJ	MGP_C3HHeJ_G0025166	protein coding gene	Chr2:22904947-22905800 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025849	protein coding gene	Chr2:23854863-23855716 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023260	protein coding gene	Chr2:21152943-21153794 (+)
CAST/EiJ	MGP_CASTEiJ_G0024629	protein coding gene	Chr2:22787831-22788676 (+)
CBA/J	MGP_CBAJ_G0025144	protein coding gene	Chr2:24694720-24695573 (+)
DBA/2J	MGP_DBA2J_G0025277	protein coding gene	Chr2:22077446-22078299 (+)
FVB/NJ	MGP_FVBNJ_G0025239	protein coding gene	Chr2:21817332-21818185 (+)
LP/J	MGP_LPJ_G0025363	protein coding gene	Chr2:23066290-23067143 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025270	protein coding gene	Chr2:24896807-24897660 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025908	protein coding gene	Chr2:22924851-22925704 (+)
PWK/PhJ	MGP_PWKPhJ_G0024377	protein coding gene	Chr2:21888822-21889673 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024177	protein coding gene	Chr2:23080486-23081337 (+)
WSB/EiJ	MGP_WSBEiJ_G0024698	protein coding gene	Chr2:22994562-22995415 (+)

Human Ortholog

TMEM203, transmembrane protein 203

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM203, transmembrane protein 203
Synonyms

HBEBP1
Links

HGNC:28217

NCBI Gene ID: 94107

neXtProt AC: NX_Q969S6

UniProt: Q969S6
Chr Location

9q34.3; chr9:137204082-137205648 (-) GRCh38

MGI Vertebrate Homology

Tmem203 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM203
Gene Tree

Tmem203

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced body weight, abnormal calcium homeostasis, arreasted spermiation, azoospermia, male infertility and reduced total litter numbers in female mice.

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All GO Annotations

10
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

25
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem203

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS38070.1

Ensembl

ENSMUSG00000078201 (Evidence)
NCBI Gene

227615

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078201	Ensembl Gene Model \| MGI Sequence Detail	854	C57BL/6J	± kb
transcript	ENSMUST00000104998	Ensembl \| MGI Sequence Detail	854	Not Applicable
polypeptide	ENSMUSP00000100614	Ensembl \| MGI Sequence Detail	136	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032381 transmembrane protein 203

(term hierarchy)
InterPro Domains

IPR019396 Transmembrane Fragile-X-F-associated protein

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All nucleic 25

cDNA 25

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem203:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16677	Chr2:25145451-25145498 (+)	24 bp
Tssr16678	Chr2:25145677-25145697 (+)	236 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24