Nrn1l MGI Mouse Gene Detail - MGI:2443642

Symbol

Nrn1l
Name

neuritin 1-like
Synonyms

G630049C14Rik

Feature Type

protein coding gene
IDs

MGI:2443642
NCBI Gene: 234700
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:106620199-106621655 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.06 cM
Mapping Data

1 experiment

SNPs within 2kb

93 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443642	protein coding gene	Chr8:106620199-106621655 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034065	protein coding gene	Chr8:108213798-108215254 (+)
A/J	MGP_AJ_G0034046	protein coding gene	Chr8:103886776-103888232 (+)
AKR/J	MGP_AKRJ_G0033972	protein coding gene	Chr8:106889141-106890597 (+)
BALB/cJ	MGP_BALBcJ_G0034039	protein coding gene	Chr8:104073430-104074886 (+)
C3H/HeJ	MGP_C3HHeJ_G0033751	protein coding gene	Chr8:107631474-107632930 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034559	protein coding gene	Chr8:112187082-112188538 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031501	protein coding gene	Chr8:97026487-97027940 (+)
CAST/EiJ	MGP_CASTEiJ_G0033077	protein coding gene	Chr8:107149982-107151438 (+)
CBA/J	MGP_CBAJ_G0033724	protein coding gene	Chr8:115788330-115789786 (+)
DBA/2J	MGP_DBA2J_G0033879	protein coding gene	Chr8:103232775-103234231 (+)
FVB/NJ	MGP_FVBNJ_G0033824	protein coding gene	Chr8:102165384-102166840 (+)
LP/J	MGP_LPJ_G0033970	protein coding gene	Chr8:108426202-108427658 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033868	protein coding gene	Chr8:118984464-118985920 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034577	protein coding gene	Chr8:106855128-106856584 (+)
PWK/PhJ	MGP_PWKPhJ_G0032778	protein coding gene	Chr8:102635677-102637133 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032619	protein coding gene	Chr8:105547716-105549172 (+)
WSB/EiJ	MGP_WSBEiJ_G0033193	protein coding gene	Chr8:107543299-107544755 (+)

Human Ortholog

NRN1L, neuritin 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NRN1L, neuritin 1 like
Synonyms

cpg15-2, MRCC2446, UNQ2446
Links

HGNC:29811

NCBI Gene ID: 123904

neXtProt AC: NX_Q496H8

UniProt: Q496H8
Chr Location

16q22.1; chr16:67884885-67888855 (+) GRCh38

MGI Vertebrate Homology

Nrn1l stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: NRN1L
Gene Tree

Nrn1l

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested.

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All GO Annotations

10
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

34
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS22618.1, CCDS80924.1

Ensembl

ENSMUSG00000044287 (Evidence)
NCBI Gene

234700

			Length	Strain/Species	Flank
genomic	234700	NCBI Gene Model \| MGI Sequence Detail	1457	C57BL/6J	± kb
transcript	NM_175024	RefSeq \| MGI Sequence Detail	643	Not Specified
polypeptide	Q8C4W3	UniProt \| EBI \| MGI Sequence Detail	162	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011435 neuritin-like protein

(term hierarchy)
InterPro Domains

IPR026144 Neuritin family

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 1

Summaries

All 29

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 10
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nrn1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79197	Chr8:106620174-106620208 (+)	-8 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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