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Marchf3 Gene Detail
Summary
  • Symbol
    Marchf3
  • Name
    membrane associated ring-CH-type finger 3
  • Synonyms
    6330411I15Rik, A530081L18Rik, March3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443667
    NCBI Gene: 320253
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:56894788-57058587 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 30.92 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4191 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443667
 protein coding gene Chr18:56894788-57058620 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024445
 protein coding gene Chr18:56155652-56328001 (-)
A/J MGP_AJ_G0024411
 protein coding gene Chr18:53930174-54092795 (-)
AKR/J MGP_AKRJ_G0024381
 protein coding gene Chr18:55410993-55575687 (-)
BALB/cJ MGP_BALBcJ_G0024411
 protein coding gene Chr18:54112476-54276649 (-)
C3H/HeJ MGP_C3HHeJ_G0024178
 protein coding gene Chr18:55631869-55801222 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024857
 protein coding gene Chr18:57941612-58115984 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022289
 protein coding gene Chr18:53558314-53717354 (-)
CAST/EiJ MGP_CASTEiJ_G0023652
 protein coding gene Chr18:55641602-55815413 (-)
CBA/J MGP_CBAJ_G0024148
 protein coding gene Chr18:59752890-59931488 (-)
DBA/2J MGP_DBA2J_G0024278
 protein coding gene Chr18:53626494-53790223 (-)
FVB/NJ MGP_FVBNJ_G0024245
 protein coding gene Chr18:53018670-53182114 (-)
LP/J MGP_LPJ_G0024363
 protein coding gene Chr18:56113500-56283975 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024275
 protein coding gene Chr18:61414837-61593157 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024904
 protein coding gene Chr18:55542000-55711128 (-)
PWK/PhJ MGP_PWKPhJ_G0023396
 protein coding gene Chr18:53647728-53811600 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023202
 protein coding gene Chr18:55602773-55773220 (-)
WSB/EiJ MGP_WSBEiJ_G0023715
 protein coding gene Chr18:55456516-55625975 (-)



Homology
more
  • Human Ortholog
    MARCHF3, membrane associated ring-CH-type finger 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARCHF3, membrane associated ring-CH-type finger 3
  • Synonyms
    MARCH3, MARCH-III, RNF173
  • Links
    NCBI Gene ID: 115123
    neXtProt AC: NX_Q86UD3
    UniProt: Q86UD3

  • Chr Location
    5q23.2; chr5:126867714-127030558 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout causes de-repression of interleukin 1 beta activity, which results in increased cytokine levels and increased susceptibility to infection-induced mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    64
  • cDNA Data
    8
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320253 NCBI Gene Model | MGI Sequence Detail 163800 C57BL/6J ±  kb
    transcript NM_001374227 RefSeq | MGI Sequence Detail 1830 C57BL/6  
    polypeptide Q8BRX9 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917973, MGI:2147267, MGI:6368851
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory