Dlec1 MGI Mouse Gene Detail - MGI:2443671 - deleted in lung and esophageal cancer 1

Symbol

Dlec1
Name

deleted in lung and esophageal cancer 1
Synonyms

D630005C06Rik

Feature Type

protein coding gene
IDs

MGI:2443671
NCBI Gene: 320256
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr9:118931546-118977314 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 71.32 cM
Mapping Data

1 experiment

SNPs within 2kb

1435 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443671	protein coding gene	Chr9:118927720-118977314 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035411	protein coding gene	Chr9:121816017-121861906 (+)
A/J	MGP_AJ_G0035391	protein coding gene	Chr9:117319010-117364763 (+)
AKR/J	MGP_AKRJ_G0035324	protein coding gene	Chr9:120355581-120403340 (+)
BALB/cJ	MGP_BALBcJ_G0035387	protein coding gene	Chr9:117184984-117232975 (+)
C3H/HeJ	MGP_C3HHeJ_G0035095	protein coding gene	Chr9:120824903-120871820 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035910	protein coding gene	Chr9:125162777-125209612 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032793	protein coding gene	Chr9:114512459-114556581 (+)
CAST/EiJ	MGP_CASTEiJ_G0034399	protein coding gene	Chr9:120787663-120841005 (+)
CBA/J	MGP_CBAJ_G0035062	protein coding gene	Chr9:129869211-129918442 (+)
DBA/2J	MGP_DBA2J_G0035221	protein coding gene	Chr9:116755687-116802305 (+)
FVB/NJ	MGP_FVBNJ_G0035168	protein coding gene	Chr9:115600426-115647102 (+)
LP/J	MGP_LPJ_G0035300	protein coding gene	Chr9:122167174-122214508 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035209	protein coding gene	Chr9:130854638-130902245 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035929	protein coding gene	Chr9:120744659-120791794 (+)
PWK/PhJ	MGP_PWKPhJ_G0034106	protein coding gene	Chr9:117168702-117215675 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033940	protein coding gene	Chr9:120856589-120905763 (+)
WSB/EiJ	MGP_WSBEiJ_G0034520	protein coding gene	Chr9:120630316-120677913 (+)

Human Ortholog

DLEC1, DLEC1 cilia and flagella associated protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DLEC1, DLEC1 cilia and flagella associated protein
Synonyms

CFAP81, DLC-1, DLC1, F56, FAP81
Links

HGNC:2899

NCBI Gene ID: 9940

neXtProt AC: NX_Q9Y238

UniProt: Q9Y238
Chr Location

3p22.2; chr3:38039205-38124025 (+) GRCh38

MGI Vertebrate Homology

Dlec1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DLEC1
Gene Tree

Dlec1

Diseases

1 with human DLEC1 associations

				Human Disease	Mouse Models
				acute myeloid leukemia IDs acute myeloid leukemia DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

2
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Dlec1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice hmozygous for a null allele exhibit male infertility with oligozoospermia, asthenozoospermia, and abnormal sperm morphology.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

2
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN dlec1

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All Sequences

65
RefSeq

24
UniProt

4
CCDS

CCDS52963.1

Ensembl

ENSMUSG00000038060 (Evidence)
NCBI Gene

320256

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038060	Ensembl Gene Model \| MGI Sequence Detail	45769	C57BL/6J	± kb
transcript	ENSMUST00000165231	Ensembl \| MGI Sequence Detail	5263	Not Applicable
polypeptide	ENSMUSP00000128874	Ensembl \| MGI Sequence Detail	1741	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006507 deleted in lung and esophageal cancer protein 1

(term hierarchy)
InterPro Domains

IPR033304 Deleted in lung and esophageal cancer protein 1

IPR013783 Immunoglobulin-like fold

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All nucleic 11

cDNA 11

Microarray probesets 2

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 22
Earliest

J:12215 Chubb C, Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis. J Androl. 1992 Jul-Aug;13(4):312-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dlec1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87667	Chr9:118931531-118931598 (+)	19 bp
Tssr87668	Chr9:118948693-118948726 (+)	17,164 bp
Tssr3050	Chr9:118948728-118948734 (+)	17,185 bp
Tssr87669	Chr9:118962655-118962683 (+)	31,123 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24