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Tnrc6b Gene Detail
Summary
  • Symbol
    Tnrc6b
  • Name
    trinucleotide repeat containing 6b
  • Synonyms
    2700090M07Rik, A730065C02Rik, D230019K20Rik, mKIAA1093
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443730
    NCBI Gene: 213988
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:80595514-80825286 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4159 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443730
 protein coding gene Chr15:80595514-80825287 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022103
 protein coding gene Chr15:81080750-81331540 (+)
A/J MGP_AJ_G0022064
 protein coding gene Chr15:78249994-78487289 (+)
AKR/J MGP_AKRJ_G0022039
 protein coding gene Chr15:80441526-80682545 (+)
BALB/cJ MGP_BALBcJ_G0022070
 protein coding gene Chr15:78258692-78492707 (+)
C3H/HeJ MGP_C3HHeJ_G0021841
 protein coding gene Chr15:80429956-80666367 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022513
 protein coding gene Chr15:84265848-84515486 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020043
 protein coding gene Chr15:74735667-74963978 (+)
CAST/EiJ MGP_CASTEiJ_G0021362
 protein coding gene Chr15:81164366-81409836 (+)
CBA/J MGP_CBAJ_G0021806
 protein coding gene Chr15:86914455-87160923 (+)
DBA/2J MGP_DBA2J_G0021935
 protein coding gene Chr15:77745769-77976668 (+)
FVB/NJ MGP_FVBNJ_G0021913
 protein coding gene Chr15:76779146-77011201 (+)
LP/J MGP_LPJ_G0022003
 protein coding gene Chr15:81251706-81496716 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021933
 protein coding gene Chr15:91918187-92157166 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022527
 protein coding gene Chr15:80485016-80725796 (+)
PWK/PhJ MGP_PWKPhJ_G0021104
 protein coding gene Chr15:77757080-77992734 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020941
 protein coding gene Chr15:80284158-80521630 (+)
WSB/EiJ MGP_WSBEiJ_G0021414
 protein coding gene Chr15:80892660-81131526 (+)



Homology
more
  • Human Ortholog
    TNRC6B, trinucleotide repeat containing adaptor 6B
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNRC6B, trinucleotide repeat containing adaptor 6B
  • Synonyms
    GDSBA
  • Links
    NCBI Gene ID: 23112
    neXtProt AC: NX_Q9UPQ9
    UniProt: Q9UPQ9

  • Chr Location
    22q13.1; chr22:40044817-40335808 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TNRC6B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit neonatal and postnatal lethality with decreased body weight and infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    2
  • cDNA Data
    19
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047888 Ensembl Gene Model | MGI Sequence Detail 229773 C57BL/6J ±  kb
    transcript ENSMUST00000067689 Ensembl | MGI Sequence Detail 17332 Not Applicable  
    polypeptide ENSMUSP00000064336 Ensembl | MGI Sequence Detail 1810 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000016519 trinucleotide repeat-containing gene 6B protein
      (term hierarchy)
    • InterPro Domains
      IPR019486 Argonaute hook domain
      IPR052068 GW182 domain-containing protein
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR034925 TNRC6B, RNA recognition motif
      IPR032226 TNRC6, PABC binding domain
    • GlyGen
      Q8BKI2 10 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919875, MGI:2146082, MGI:2442182
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 38
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory