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Large2 Gene Detail
Summary
  • Symbol
    Large2
  • Name
    LARGE xylosyl- and glucuronyltransferase 2
  • Synonyms
    5730485C17Rik, Gyltl1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443769
    NCBI Gene: 228366
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:92195391-92201437 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443769
 protein coding gene Chr2:92195391-92205214 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026164
 protein coding gene Chr2:93795710-93805533 (-)
A/J MGP_AJ_G0026125
 protein coding gene Chr2:89998676-90008497 (-)
AKR/J MGP_AKRJ_G0026106
 protein coding gene Chr2:92486187-92497777 (-)
BALB/cJ MGP_BALBcJ_G0026134
 protein coding gene Chr2:90183048-90192868 (-)
C3H/HeJ MGP_C3HHeJ_G0025885
 protein coding gene Chr2:92793523-92803715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026585
 protein coding gene Chr2:97010608-97020815 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023976
 protein coding gene Chr2:86490217-86500815 (-)
CAST/EiJ MGP_CASTEiJ_G0025350
 protein coding gene Chr2:93340045-93349883 (-)
CBA/J MGP_CBAJ_G0025863
 protein coding gene Chr2:100396975-100406798 (-)
DBA/2J MGP_DBA2J_G0025999
 protein coding gene Chr2:89591738-89601560 (-)
FVB/NJ MGP_FVBNJ_G0025962
 protein coding gene Chr2:88702000-88712368 (-)
LP/J MGP_LPJ_G0026103
 protein coding gene Chr2:93991775-94001596 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025988
 protein coding gene Chr2:103355424-103365247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026639
 protein coding gene Chr2:92571509-92581331 (-)
PWK/PhJ MGP_PWKPhJ_G0025085
 protein coding gene Chr2:89337280-89347183 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024886
 protein coding gene Chr2:92140971-92151516 (-)
WSB/EiJ MGP_WSBEiJ_G0025417
 protein coding gene Chr2:93189557-93199378 (-)



Homology
more
  • Human Ortholog
    LARGE2, LARGE xylosyl- and glucuronyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LARGE2, LARGE xylosyl- and glucuronyltransferase 2
  • Synonyms
    GYLTL1B, PP5656
  • Links
    NCBI Gene ID: 120071
    neXtProt AC: NX_Q8N3Y3
    UniProt: Q8N3Y3

  • Chr Location
    11p11.2; chr11:45921621-45929096 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutant mice are healthy and are indistinguishable from control littermates with respect to body weight and life span when aged up to one year. No increased spontaneous tumor load was observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    923
  • Tissues
    28
  • cDNA Data
    41
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 228366 NCBI Gene Model | MGI Sequence Detail 6047 C57BL/6J ±  kb
transcript NM_001290775 RefSeq | MGI Sequence Detail 2673 C57BL/6  
polypeptide Q5XPT3 UniProt | EBI | MGI Sequence Detail 690 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    Genomic 1
    cDNA 42
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2139110
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory