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Kctd8 Gene Detail
Summary
  • Symbol
    Kctd8
  • Name
    potassium channel tetramerisation domain containing 8
  • Synonyms
    A730087N02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443804
    NCBI Gene: 243043
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:69266628-69499022 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 37.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6786 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443804
 protein coding gene Chr5:69266628-69499052 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029601
 protein coding gene Chr5:68948801-69189200 (-)
A/J MGP_AJ_G0029569
 protein coding gene Chr5:66352929-66582974 (-)
AKR/J MGP_AKRJ_G0029517
 protein coding gene Chr5:68470032-68704233 (-)
BALB/cJ MGP_BALBcJ_G0029578
 protein coding gene Chr5:67029270-67264028 (-)
C3H/HeJ MGP_C3HHeJ_G0029301
 protein coding gene Chr5:68824697-69065217 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030032
 protein coding gene Chr5:71813871-72057599 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027272
 protein coding gene Chr5:62316496-62547648 (-)
CAST/EiJ MGP_CASTEiJ_G0028709
 protein coding gene Chr5:67961819-68219664 (-)
CBA/J MGP_CBAJ_G0029270
 protein coding gene Chr5:74129276-74390203 (-)
DBA/2J MGP_DBA2J_G0029416
 protein coding gene Chr5:66380198-66611128 (-)
FVB/NJ MGP_FVBNJ_G0029376
 protein coding gene Chr5:65625076-65866703 (-)
LP/J MGP_LPJ_G0029501
 protein coding gene Chr5:69415596-69652695 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029404
 protein coding gene Chr5:77044277-77329448 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030065
 protein coding gene Chr5:68127051-68362376 (-)
PWK/PhJ MGP_PWKPhJ_G0028433
 protein coding gene Chr5:65405031-65645020 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028267
 protein coding gene Chr5:67493143-67735018 (-)
WSB/EiJ MGP_WSBEiJ_G0028789
 protein coding gene Chr5:68355985-68607272 (-)



Homology
more
  • Human Ortholog
    KCTD8, potassium channel tetramerization domain containing 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCTD8, potassium channel tetramerization domain containing 8
  • Links
    NCBI Gene ID: 386617
    neXtProt AC: NX_Q6ZWB6
    UniProt: Q6ZWB6

  • Chr Location
    4p13; chr4:44173903-44448809 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    16
  • cDNA Data
    11
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037653 Ensembl Gene Model | MGI Sequence Detail 232395 C57BL/6J ±  kb
transcript ENSMUST00000054095 Ensembl | MGI Sequence Detail 2859 Not Applicable  
polypeptide ENSMUSP00000055326 Ensembl | MGI Sequence Detail 476 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031995 BTB/POZ domain-containing protein KCTD8
    (term hierarchy)
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR049904 Potassium channel tetramerization domain-containing protein 8, H1 domain
    IPR011333 SKP1/BTB/POZ domain superfamily
  • GlyGen
    Q50H33 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 19
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:332917 Ren Y, et al., KCTD8 and KCTD12 Facilitate Axonal Expression of GABA(B) Receptors in Habenula Cholinergic Neurons. J Neurosci. 2022 Mar 2;42(9):1648-1665
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory