Tsku MGI Mouse Gene Detail - MGI:2443855 - tsukushi, small leucine rich proteoglycan

Symbol

Tsku
Name

tsukushi, small leucine rich proteoglycan
Synonyms

9530051K01Rik, Lrrc54

Feature Type

protein coding gene
IDs

MGI:2443855
NCBI Gene: 244152
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:97999875-98010535 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 53.66 cM
Mapping Data

1 experiment

SNPs within 2kb

397 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443855	protein coding gene	Chr7:97999875-98010602 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032538	protein coding gene	Chr7:101073466-101084118 (-)
A/J	MGP_AJ_G0032512	protein coding gene	Chr7:98580750-98591413 (-)
AKR/J	MGP_AKRJ_G0032448	protein coding gene	Chr7:100923572-100934232 (-)
BALB/cJ	MGP_BALBcJ_G0032523	protein coding gene	Chr7:98270215-98280863 (-)
C3H/HeJ	MGP_C3HHeJ_G0032238	protein coding gene	Chr7:101277352-101287888 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033021	protein coding gene	Chr7:104994434-105005088 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030016	protein coding gene	Chr7:101022736-101034241 (-)
CAST/EiJ	MGP_CASTEiJ_G0031565	protein coding gene	Chr7:92793516-92804083 (-)
CBA/J	MGP_CBAJ_G0032205	protein coding gene	Chr7:108566652-108577188 (-)
DBA/2J	MGP_DBA2J_G0032357	protein coding gene	Chr7:96909103-96919639 (-)
FVB/NJ	MGP_FVBNJ_G0032313	protein coding gene	Chr7:96713405-96724037 (-)
LP/J	MGP_LPJ_G0032446	protein coding gene	Chr7:102405205-102415859 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032346	protein coding gene	Chr7:110103449-110114105 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033043	protein coding gene	Chr7:100193580-100204231 (-)
PWK/PhJ	MGP_PWKPhJ_G0031283	protein coding gene	Chr7:89996958-90007609 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031126	protein coding gene	Chr7:87470372-87481674 (-)
WSB/EiJ	MGP_WSBEiJ_G0031682	protein coding gene	Chr7:100853470-100864120 (-)

Human Ortholog

TSKU, tsukushi, small leucine rich proteoglycan

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSKU, tsukushi, small leucine rich proteoglycan
Synonyms

E2IG4, LRRC54, TSK
Links

HGNC:28850

NCBI Gene ID: 25987

neXtProt AC: NX_Q8WUA8

UniProt: Q8WUA8
Chr Location

11q13.5; chr11:76782251-76798153 (+) GRCh38

MGI Vertebrate Homology

Tsku stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TSKU
Gene Tree

Tsku

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Tsku
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a failure of anterior commissure axons to cross the midline.

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All GO Annotations

26
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

38
cDNA Data

14
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tsku

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All Sequences

66
RefSeq

20
UniProt

2
CCDS

CCDS21469.1

Ensembl

ENSMUSG00000049580 (Evidence)
NCBI Gene

244152

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049580	Ensembl Gene Model \| MGI Sequence Detail	10661	C57BL/6J	± kb
transcript	ENSMUST00000164726	Ensembl \| MGI Sequence Detail	2620	Not Applicable
polypeptide	ENSMUSP00000130917	Ensembl \| MGI Sequence Detail	354	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016729 tsukushi

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR050328 Multifunctional Developmental and Immune Receptor
GlyGen

Q8CBR6 3 sites

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All nucleic 16

cDNA 14

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 51

Developmental Gene Expression 9

Gene Ontology 12

Phenotypes 29
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:331988 Istiaq A, et al., Tsukushi proteoglycan maintains RNA splicing and developmental signaling network in GFAP-expressing subventricular zone neural stem/progenitor cells. Front Cell Dev Biol. 2022;10:994588

TSS for Tsku:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73630	Chr7:98010702-98010711 (-)	-172 bp
Tssr73629	Chr7:98010600-98010608 (-)	-69 bp
Tssr73628	Chr7:98010534-98010550 (-)	-7 bp
Tssr73627	Chr7:98010517-98010527 (-)	13 bp
Tssr73626	Chr7:98010482-98010502 (-)	43 bp
Tssr73625	Chr7:98010455-98010462 (-)	76 bp
Tssr73624	Chr7:98009642-98009677 (-)	875 bp
Tssr73623	Chr7:98000145-98000151 (-)	10,387 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24