Lyset MGI Mouse Gene Detail - MGI:2443862 - lysosomal enzyme trafficking factor

Symbol

Lyset
Name

lysosomal enzyme trafficking factor
Synonyms

D230037D09Rik, Tmem251

Feature Type

protein coding gene
IDs

MGI:2443862
NCBI Gene: 320351
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:102710021-102713820 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 52.15 cM
Mapping Data

1 experiment

SNPs within 2kb

121 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443862	protein coding gene	Chr12:102709978-102714551 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020038	protein coding gene	Chr12:104401676-104405477 (+)
A/J	MGP_AJ_G0019994	protein coding gene	Chr12:100383265-100387066 (+)
AKR/J	MGP_AKRJ_G0019970	protein coding gene	Chr12:103224879-103228680 (+)
BALB/cJ	MGP_BALBcJ_G0019980	protein coding gene	Chr12:100734906-100738707 (+)
C3H/HeJ	MGP_C3HHeJ_G0019782	protein coding gene	Chr12:103698201-103702002 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020429	protein coding gene	Chr12:107637755-107641556 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018042	protein coding gene	Chr12:97397030-97401016 (+)
CAST/EiJ	MGP_CASTEiJ_G0019328	protein coding gene	Chr12:98541420-98545231 (+)
CBA/J	MGP_CBAJ_G0019754	protein coding gene	Chr12:111642382-111646183 (+)
DBA/2J	MGP_DBA2J_G0019865	protein coding gene	Chr12:99901185-99904986 (+)
FVB/NJ	MGP_FVBNJ_G0019854	protein coding gene	Chr12:98633199-98637000 (+)
LP/J	MGP_LPJ_G0019941	protein coding gene	Chr12:104241972-104245773 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019894	protein coding gene	Chr12:115100356-115104157 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020458	protein coding gene	Chr12:102738687-102742488 (+)
PWK/PhJ	MGP_PWKPhJ_G0019091	protein coding gene	Chr12:94459527-94463338 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018887	protein coding gene	Chr12:96939111-96942918 (+)
WSB/EiJ	MGP_WSBEiJ_G0019382	protein coding gene	Chr12:103631420-103635221 (+)

Human Ortholog

LYSET, lysosomal enzyme trafficking factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LYSET, lysosomal enzyme trafficking factor
Synonyms

C14orf109, DMAN, GCAF, TMEM251
Links

HGNC:20218

NCBI Gene ID: 26175

neXtProt AC: NX_Q8N6I4

UniProt: Q8N6I4
Chr Location

14q32.12; chr14:93184951-93188463 (+) GRCh38

MGI Vertebrate Homology

Lyset stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LYSET
Gene Tree

Lyset

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Phenotype Summary

4 phenotypes from 2 alleles in 3 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Genomic Mutations

1 involving Lyset
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

5 strains or lines available

Mice homozygous for a null allele show increased levels of lysosomal enzymes, increase in and larger lysosomes, storage materials in lysosomes and MEFs resistant to infection with Ebola virus glycoprotein.

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All GO Annotations

12
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

20

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lyset

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All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS49146.1

Ensembl

ENSMUSG00000046675 (Evidence)
NCBI Gene

320351

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046675	Ensembl Gene Model \| MGI Sequence Detail	3800	C57BL/6J	± kb
transcript	ENSMUST00000057416	Ensembl \| MGI Sequence Detail	3367	Not Applicable
polypeptide	ENSMUSP00000054611	Ensembl \| MGI Sequence Detail	163	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032764 lysosomal enzyme trafficking factor

(term hierarchy)
InterPro Domains

IPR028024 Lysosomal enzyme trafficking factor

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All nucleic 20

cDNA 20

Microarray probesets 2

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MGI:7413971

Summaries

All 27

Gene Ontology 5

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:330704 Richards CM, et al., The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection. Science. 2022 Sep 8;:eabn5648

TSS for Lyset:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114771	Chr12:102709958-102709970 (+)	-57 bp
Tssr114772	Chr12:102709971-102710006 (+)	-32 bp
Tssr114773	Chr12:102710009-102710035 (+)	1 bp
Tssr114774	Chr12:102710050-102710061 (+)	35 bp
Tssr114775	Chr12:102710234-102710244 (+)	218 bp
Tssr114776	Chr12:102710251-102710267 (+)	238 bp
Tssr114777	Chr12:102710280-102710306 (+)	272 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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