Bcorl1 MGI Mouse Gene Detail - MGI:2443910

Symbol

Bcorl1
Name

BCL6 co-repressor-like 1
Synonyms

6720425J07Rik

Feature Type

protein coding gene
IDs

MGI:2443910
NCBI Gene: 320376
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

ChrX:47430235-47496926 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 25.64 cM
Mapping Data

2 experiments

SNPs within 2kb

1157 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443910	protein coding gene	ChrX:47430235-47496945 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035691	protein coding gene	ChrX:43499956-43567706 (+)
A/J	MGP_AJ_G0035674	protein coding gene	ChrX:43357490-43423773 (+)
AKR/J	MGP_AKRJ_G0035594	protein coding gene	ChrX:44558568-44626269 (+)
BALB/cJ	MGP_BALBcJ_G0035660	protein coding gene	ChrX:43004439-43068465 (+)
C3H/HeJ	MGP_C3HHeJ_G0035364	protein coding gene	ChrX:43789509-43855251 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036189	protein coding gene	ChrX:44518456-44588924 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033041	protein coding gene	ChrX:41052388-41116082 (+)
CAST/EiJ	MGP_CASTEiJ_G0034655	protein coding gene	ChrX:31369350-31436331 (+)
CBA/J	MGP_CBAJ_G0035338	protein coding gene	ChrX:45767872-45844512 (+)
DBA/2J	MGP_DBA2J_G0035492	protein coding gene	ChrX:43199765-43264253 (+)
FVB/NJ	MGP_FVBNJ_G0035441	protein coding gene	ChrX:42918095-42982989 (+)
LP/J	MGP_LPJ_G0035580	protein coding gene	ChrX:43845725-43913923 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035479	protein coding gene	ChrX:47209403-47273059 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036207	protein coding gene	ChrX:43395294-43465526 (+)
PWK/PhJ	MGP_PWKPhJ_G0034354	protein coding gene	ChrX:30848384-30916119 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034199	protein coding gene	ChrX:32157799-32221340 (+)
WSB/EiJ	MGP_WSBEiJ_G0034799	protein coding gene	ChrX:43036690-43107161 (+)

Human Ortholog

BCORL1, BCL6 corepressor like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCORL1, BCL6 corepressor like 1
Synonyms

BCoR-L1, CXorf10, SHUVER
Links

HGNC:25657

NCBI Gene ID: 63035

neXtProt AC: NX_Q5H9F3

UniProt: Q5H9F3
Chr Location

Xq26.1; chrX:129980313-130058071 (+) GRCh38

MGI Vertebrate Homology

Bcorl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BCORL1
Gene Tree

Bcorl1

Diseases

1 with human BCORL1 associations

				Human Disease	Mouse Models
				Shukla-Vernon syndrome IDs Shukla-Vernon syndrome DOID:0111841 OMIM:301029

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

26 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility with oligozoospermia and abnormal sperm mitochondrial sheath morphology with large vacuoles.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

5
cDNA Data

29
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bcorl1

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All Sequences

60
RefSeq

16
UniProt

4
CCDS

CCDS40961.1

Ensembl

ENSMUSG00000036959 (Evidence)
NCBI Gene

320376

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036959	Ensembl Gene Model \| MGI Sequence Detail	66692	C57BL/6J	± kb
transcript	ENSMUST00000136348	Ensembl \| MGI Sequence Detail	7446	Not Applicable
polypeptide	ENSMUSP00000122000	Ensembl \| MGI Sequence Detail	1781	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004710 BCL-6 corepressor-like protein 1

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR047144 BCL-6 corepressor-like

IPR032365 BCL-6 corepressor, PCGF1 binding domain

IPR038227 PCGF Ub-like fold discriminator superfamily
GlyGen

A2AQH4 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 29

cDNA 29

Microarray probesets 3

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MGI:1925143

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bcorl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160895	ChrX:47430221-47430295 (+)	23 bp
Tssr160896	ChrX:47430934-47430950 (+)	707 bp
Tssr160897	ChrX:47432579-47432600 (+)	2,355 bp
Tssr160898	ChrX:47432635-47432653 (+)	2,409 bp
Tssr160899	ChrX:47436388-47436392 (+)	6,155 bp
Tssr160900	ChrX:47457019-47457034 (+)	26,792 bp
Tssr160901	ChrX:47489402-47489418 (+)	59,175 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24