Mmp25 MGI Mouse Gene Detail - MGI:2443938 - matrix metallopeptidase 25

Symbol

Mmp25
Name

matrix metallopeptidase 25
Synonyms

F730048C11Rik, Leukolysin, MT6-MMP

Feature Type

protein coding gene
IDs

MGI:2443938
NCBI Gene: 240047
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:23847289-23864006 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 11.87 cM
Mapping Data

1 experiment

SNPs within 2kb

533 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443938	protein coding gene	Chr17:23847285-23864251 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023259	protein coding gene	Chr17:22532716-22554162 (-)
A/J	MGP_AJ_G0023219	protein coding gene	Chr17:21891572-21908430 (-)
AKR/J	MGP_AKRJ_G0023189	protein coding gene	Chr17:21970199-21985857 (-)
BALB/cJ	MGP_BALBcJ_G0023224	protein coding gene	Chr17:22107550-22124652 (-)
C3H/HeJ	MGP_C3HHeJ_G0022984	protein coding gene	Chr17:22328871-22346919 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023667	protein coding gene	Chr17:23519240-23535883 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021148	protein coding gene	Chr17:19464503-19480058 (-)
CAST/EiJ	MGP_CASTEiJ_G0022490	protein coding gene	Chr17:22162146-22179923 (-)
CBA/J	MGP_CBAJ_G0022960	protein coding gene	Chr17:24313919-24341051 (-)
DBA/2J	MGP_DBA2J_G0023092	protein coding gene	Chr17:21520718-21538914 (-)
FVB/NJ	MGP_FVBNJ_G0023059	protein coding gene	Chr17:21243952-21263766 (-)
LP/J	MGP_LPJ_G0023166	protein coding gene	Chr17:22790769-22807045 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023078	protein coding gene	Chr17:24092290-24110511 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023706	protein coding gene	Chr17:22256371-22273016 (-)
PWK/PhJ	MGP_PWKPhJ_G0022238	protein coding gene	Chr17:20307224-20323808 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022058	protein coding gene	Chr17:20285913-20301445 (-)
WSB/EiJ	MGP_WSBEiJ_G0022553	protein coding gene	Chr17:22314448-22332526 (-)

Human Ortholog

MMP25, matrix metallopeptidase 25

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MMP25, matrix metallopeptidase 25
Synonyms

MMP20, MMP20A, MMP-25, MMPL1, MT6-MMP, MT6MMP, MT-MMP 6, MT-MMP6, MTMMP6
Links

HGNC:14246

NCBI Gene ID: 64386

neXtProt AC: NX_Q9NPA2

UniProt: Q9NPA2
Chr Location

16p13.3; chr16:3046062-3060726 (+) GRCh38

MGI Vertebrate Homology

Mmp25 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: MMP25
Protein SuperFamily

Peptidase_M10A_matrix
Gene Tree

Mmp25

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Phenotype Summary

9 phenotypes from 2 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

3
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display impaired angiogenic sprouting in the brain and impaired innate immune responses.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

14
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mmp25

ZFIN mmp25a, mmp25b

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All Sequences

42
RefSeq

6
UniProt

3
CCDS

CCDS28452.1

Ensembl

ENSMUSG00000023903 (Evidence)
NCBI Gene

240047

			Length	Strain/Species	Flank
genomic	240047	NCBI Gene Model \| MGI Sequence Detail	16718	C57BL/6J	± kb
transcript	NM_001033339	RefSeq \| MGI Sequence Detail	4279	C57BL/6
polypeptide	Q3U435	UniProt \| EBI \| MGI Sequence Detail	615	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010484 matrix metalloproteinase-25

(term hierarchy)
EC

3.4.24.-
InterPro Domains

IPR000585 Hemopexin-like domain

IPR036375 Hemopexin-like domain superfamily

IPR018487 Hemopexin-like repeats

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR021190 Peptidase M10A

IPR033739 Peptidase M10A, catalytic domain

IPR001818 Peptidase M10, metallopeptidase

IPR006026 Peptidase, metallopeptidase

IPR002477 Peptidoglycan binding-like

IPR036365 PGBD-like superfamily

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All nucleic 15

cDNA 13

Primer pair 1

Other 1

Microarray probesets 1

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 10
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:349863 Schevenels G, et al., A brain-specific angiogenic mechanism enabled by tip cell specialization. Nature. 2024 Apr;628(8009):863-871

TSS for Mmp25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146626	Chr17:23864238-23864283 (-)	-255 bp
Tssr146625	Chr17:23864206-23864235 (-)	-215 bp
Tssr146624	Chr17:23864040-23864047 (-)	-38 bp
Tssr146623	Chr17:23864021-23864029 (-)	-19 bp
Tssr146622	Chr17:23863973-23864011 (-)	14 bp
Tssr146621	Chr17:23863953-23863970 (-)	44 bp
Tssr146620	Chr17:23863927-23863932 (-)	76 bp
Tssr146619	Chr17:23860697-23860740 (-)	3,287 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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