Zfp516 MGI Mouse Gene Detail - MGI:2443957

Symbol

Zfp516
Name

zinc finger protein 516
Synonyms

C330029B10Rik, mKIAA0222, Zfp26l

Feature Type

protein coding gene
IDs

MGI:2443957
NCBI Gene: 329003
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr18:82928788-83023439 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 57.39 cM
Mapping Data

3 experiments

SNPs within 2kb

2989 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443957	protein coding gene	Chr18:82925324-83023439 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024603	protein coding gene	Chr18:83969467-84077398 (+)
A/J	MGP_AJ_G0024570	protein coding gene	Chr18:80303657-80399774 (+)
AKR/J	MGP_AKRJ_G0024541	protein coding gene	Chr18:82676380-82778206 (+)
BALB/cJ	MGP_BALBcJ_G0024568	protein coding gene	Chr18:80494929-80589770 (+)
C3H/HeJ	MGP_C3HHeJ_G0024337	protein coding gene	Chr18:82794007-82895752 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025015	protein coding gene	Chr18:86072758-86170039 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022446	protein coding gene	Chr18:79049214-79142042 (+)
CAST/EiJ	MGP_CASTEiJ_G0023810	protein coding gene	Chr18:83155176-83232018 (+)
CBA/J	MGP_CBAJ_G0024307	protein coding gene	Chr18:89258759-89359751 (+)
DBA/2J	MGP_DBA2J_G0024437	protein coding gene	Chr18:79821571-79916219 (+)
FVB/NJ	MGP_FVBNJ_G0024403	protein coding gene	Chr18:79142027-79236139 (+)
LP/J	MGP_LPJ_G0024521	protein coding gene	Chr18:83778169-83883737 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024433	protein coding gene	Chr18:90446349-90554469 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025064	protein coding gene	Chr18:82857277-82965400 (+)
PWK/PhJ	MGP_PWKPhJ_G0023555	protein coding gene	Chr18:80213579-80330798 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023361	protein coding gene	Chr18:82951446-83126687 (+)
WSB/EiJ	MGP_WSBEiJ_G0023872	protein coding gene	Chr18:82834049-82932795 (+)

Human Ortholog

ZNF516, zinc finger protein 516

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF516, zinc finger protein 516
Synonyms

HsT287
Links

HGNC:28990

NCBI Gene ID: 9658

neXtProt AC: NX_Q92618

UniProt: Q92618
Chr Location

18q23; chr18:76357682-76496419 (-) GRCh38

MGI Vertebrate Homology

Zfp516 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF516
Gene Tree

Zfp516

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

61
Gene trapped

60
Transposon induced

1
Genomic Mutations

1 involving Zfp516
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

65 strains or lines available

Mice homozygous for a null allele die immediately after birth and show decreased white adipose tissue cell size, and abnormal presumptive brown adipose tissue morphology with abnormal mitochondria at E20.5.

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

892
Tissues

123
cDNA Data

57
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN znf516

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All Sequences

78
RefSeq

26
UniProt

7
CCDS

CCDS29380.1

Ensembl

ENSMUSG00000058881 (Evidence)
NCBI Gene

329003

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058881	Ensembl Gene Model \| MGI Sequence Detail	94652	C57BL/6J	± kb
transcript	ENSMUST00000071233	Ensembl \| MGI Sequence Detail	7703	Not Applicable
polypeptide	ENSMUSP00000071216	Ensembl \| MGI Sequence Detail	1157	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017948 zinc finger protein 516

(term hierarchy)
InterPro Domains

IPR051967 Krueppel C2H2-type Zinc-Finger Domain-Containing Protein

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q7TSH3 1 site, 1 O-linked glycan (1 site)

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All nucleic 59

cDNA 57

Primer pair 2

Microarray probesets 2

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MGI:1926951

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:319940 Yan L, et al., PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex. Adv Sci (Weinh). 2021 Aug;8(16):e2102060

TSS for Zfp516:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152189	Chr18:82928714-82928770 (+)	-46 bp
Tssr152190	Chr18:82928783-82928803 (+)	5 bp
Tssr152191	Chr18:82928964-82928987 (+)	188 bp
Tssr152192	Chr18:82928988-82929010 (+)	211 bp
Tssr152193	Chr18:82929011-82929026 (+)	231 bp
Tssr152194	Chr18:82929038-82929068 (+)	265 bp
Tssr152195	Chr18:82929451-82929458 (+)	667 bp
Tssr152196	Chr18:82932763-82932789 (+)	3,988 bp
Tssr152197	Chr18:82990896-82990918 (+)	62,119 bp
Tssr5391	Chr18:83015207-83015212 (+)	86,422 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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