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Creb5 Gene Detail
Summary
  • Symbol
    Creb5
  • Name
    cAMP responsive element binding protein 5
  • Synonyms
    9430076C15Rik, Crebpa, D430026C09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443973
    NCBI Gene: 231991
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:53264255-53677361 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11000 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443973
 protein coding gene Chr6:53264154-53677361 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030755
 protein coding gene Chr6:52601678-53027315 (+)
A/J MGP_AJ_G0030724
 protein coding gene Chr6:50145008-50555025 (+)
AKR/J MGP_AKRJ_G0030651
 protein coding gene Chr6:51877490-52286271 (+)
BALB/cJ MGP_BALBcJ_G0030736
 protein coding gene Chr6:50493341-50909384 (+)
C3H/HeJ MGP_C3HHeJ_G0030449
 protein coding gene Chr6:51888748-52301120 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031191
 protein coding gene Chr6:53760564-54203692 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028397
 protein coding gene Chr6:47776493-48175764 (+)
CAST/EiJ MGP_CASTEiJ_G0029852
 protein coding gene Chr6:51712729-52139099 (+)
CBA/J MGP_CBAJ_G0030423
 protein coding gene Chr6:55997079-56439283 (+)
DBA/2J MGP_DBA2J_G0030573
 protein coding gene Chr6:50054024-50460072 (+)
FVB/NJ MGP_FVBNJ_G0030525
 protein coding gene Chr6:49655671-50055923 (+)
LP/J MGP_LPJ_G0030658
 protein coding gene Chr6:52550633-52972539 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030559
 protein coding gene Chr6:58592749-59011511 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031221
 protein coding gene Chr6:51809294-52223579 (+)
PWK/PhJ MGP_PWKPhJ_G0029565
 protein coding gene Chr6:49683935-50098663 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029399
 protein coding gene Chr6:51165936-51584748 (+)
WSB/EiJ MGP_WSBEiJ_G0029929
 protein coding gene Chr6:51826303-52241130 (+)



Homology
more
  • Human Ortholog
    CREB5, cAMP responsive element binding protein 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREB5, cAMP responsive element binding protein 5
  • Synonyms
    CREB-5, CRE-BPA, CREBPA
  • Links
    NCBI Gene ID: 9586
    neXtProt AC: NX_Q02930
    UniProt: Q02930

  • Chr Location
    7p15.1-p14.3; chr7:28299321-28825894 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    26
  • cDNA Data
    43
  • Literature Summary
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053007 Ensembl Gene Model | MGI Sequence Detail 413107 C57BL/6J ±  kb
transcript ENSMUST00000203487 Ensembl | MGI Sequence Detail 2648 Not Applicable  
polypeptide ENSMUSP00000144851 Ensembl | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000005860 cyclic AMP-responsive element-binding protein 5
    (term hierarchy)
  • InterPro Domains
    IPR051027 Basic leucine zipper (bZIP) transcription factors
    IPR004827 Basic-leucine zipper domain
    IPR046347 Basic-leucine zipper domain superfamily
    IPR016378 Transcription factor cyclic AMP-dependent, CRE-BP1-type
    IPR036236 Zinc finger C2H2 superfamily
    IPR013087 Zinc finger C2H2-type
Molecular
Reagents
less
  • All nucleic 46
    cDNA 43
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2443551
References
more
  • Summaries
    All 40
    Developmental Gene Expression 15
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:341969 Jacob T, et al., Molecular and spatial landmarks of early mouse skin development. Dev Cell. 2023 Oct 23;58(20):2140-2162.e5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory