About   Help   FAQ
Gchfr Gene Detail
Summary
  • Symbol
    Gchfr
  • Name
    GTP cyclohydrolase I feedback regulator
  • Synonyms
    2010323F13Rik, P35
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443977
    NCBI Gene: 320415
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118998269-119002870 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443977
 protein coding gene Chr2:118998254-119002871 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026333
 protein coding gene Chr2:121902797-121907094 (+)
A/J MGP_AJ_G0026294
 protein coding gene Chr2:116942252-116946573 (+)
AKR/J MGP_AKRJ_G0026273
 protein coding gene Chr2:120214900-120219216 (+)
BALB/cJ MGP_BALBcJ_G0026307
 protein coding gene Chr2:117206027-117210342 (+)
C3H/HeJ MGP_C3HHeJ_G0026053
 protein coding gene Chr2:120683721-120688055 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026754
 protein coding gene Chr2:125906602-125911218 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024134
 protein coding gene Chr2:111996913-112001518 (+)
CAST/EiJ MGP_CASTEiJ_G0025515
 protein coding gene Chr2:120990189-120994507 (+)
CBA/J MGP_CBAJ_G0026029
 protein coding gene Chr2:130341219-130345535 (+)
DBA/2J MGP_DBA2J_G0026168
 protein coding gene Chr2:116369434-116373733 (+)
FVB/NJ MGP_FVBNJ_G0026130
 protein coding gene Chr2:115188534-115192850 (+)
LP/J MGP_LPJ_G0026269
 protein coding gene Chr2:122216749-122221070 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026149
 protein coding gene Chr2:134702589-134706889 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026809
 protein coding gene Chr2:120338771-120343079 (+)
PWK/PhJ MGP_PWKPhJ_G0025251
 protein coding gene Chr2:115923504-115928261 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025050
 protein coding gene Chr2:119524961-119529605 (+)
WSB/EiJ MGP_WSBEiJ_G0025584
 protein coding gene Chr2:121166249-121171362 (+)



Homology
more
  • Human Ortholog
    GCHFR, GTP cyclohydrolase I feedback regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCHFR, GTP cyclohydrolase I feedback regulator
  • Synonyms
    GFRP, HsT16933, P35
  • Links
    NCBI Gene ID: 2644
    neXtProt AC: NX_P30047
    UniProt: P30047

  • Chr Location
    15q15.1; chr15:40764068-40767708 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    4
  • cDNA Data
    37
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 320415 NCBI Gene Model | MGI Sequence Detail 4602 C57BL/6J ±  kb
transcript NM_177157 RefSeq | MGI Sequence Detail 629 C57BL/6  
polypeptide P99025 UniProt | EBI | MGI Sequence Detail 84 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 38

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:237675 Wyler SC, et al., Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS Chem Neurosci. 2015 Jul 15;6(7):1198-205
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory