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Amdhd2 Gene Detail
Summary
  • Symbol
    Amdhd2
  • Name
    amidohydrolase domain containing 2
  • Synonyms
    5730457F11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443978
    NCBI Gene: 245847
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24374807-24382740 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443978
 protein coding gene Chr17:24374807-24382752 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023289
 protein coding gene Chr17:23108619-23117833 (-)
A/J MGP_AJ_G0023249
 protein coding gene Chr17:22508677-22516645 (-)
AKR/J MGP_AKRJ_G0023216
 protein coding gene Chr17:22570257-22578097 (-)
BALB/cJ MGP_BALBcJ_G0023254
 protein coding gene Chr17:22683707-22693366 (-)
C3H/HeJ MGP_C3HHeJ_G0023014
 protein coding gene Chr17:22905090-22913666 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023697
 protein coding gene Chr17:24152292-24161638 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021174
 protein coding gene Chr17:19967635-19976045 (-)
CAST/EiJ MGP_CASTEiJ_G0022516
 protein coding gene Chr17:22748545-22756509 (-)
CBA/J MGP_CBAJ_G0022990
 protein coding gene Chr17:24980764-24989489 (-)
DBA/2J MGP_DBA2J_G0023119
 protein coding gene Chr17:22082260-22090228 (-)
FVB/NJ MGP_FVBNJ_G0023089
 protein coding gene Chr17:21797966-21806414 (-)
LP/J MGP_LPJ_G0023196
 protein coding gene Chr17:23426081-23434049 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023108
 protein coding gene Chr17:24699187-24708123 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023735
 protein coding gene Chr17:22837472-22846294 (-)
PWK/PhJ MGP_PWKPhJ_G0022265
 protein coding gene Chr17:20838785-20846897 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022084
 protein coding gene Chr17:20863247-20871380 (-)
WSB/EiJ MGP_WSBEiJ_G0022579
 protein coding gene Chr17:22897118-22911120 (-)



Homology
more
  • Human Ortholog
    AMDHD2, amidohydrolase domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMDHD2, amidohydrolase domain containing 2
  • Synonyms
    CGI-14
  • Links
    NCBI Gene ID: 51005
    neXtProt AC: NX_Q9Y303
    UniProt: Q9Y303

  • Chr Location
    16p13.3; chr16:2520357-2531422 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    95
  • cDNA Data
    47
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036820 Ensembl Gene Model | MGI Sequence Detail 7934 C57BL/6J ±  kb
transcript ENSMUST00000129523 Ensembl | MGI Sequence Detail 1526 Not Applicable  
polypeptide ENSMUSP00000120520 Ensembl | MGI Sequence Detail 453 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:324170 Kroef V, et al., GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. Elife. 2022 Mar 1;11:e69223
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory